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Dr. Gary
Dr. Gary, Veterinarian
Category: Veterinary
Satisfied Customers: 19798
Experience:  DVM, Emergency Veterinarian, BS (Physiology)
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What types of morphological changes would be seen on a blood

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What types of morphological changes would be seen on a blood smear with chemically induces liver toxicity in animals? are there any good references books out there?
Hello, I'm Dr Gary. I've been practicing veterinary medicine since 2007. I look forward to helping with your questions/ concerns.

Sorry about the long wait.

I would recommend a book called Veterinary Hematology and Clinical Chemistry. Another great one is Diagnostic Cytology and Hematology.

When there is liver toxicity, we don't usually see a whole lot on the blood smear. We'll often see a mildly regenerative anemia with a chronic disease state. We'll have a mild anisocytosis and polychromasia.

When we're looking at heavy metal toxicities, one of the characteristic findings is nucleated red blood cells on the smear. We can also see some hypochromasia and increased pallor of the red cells.

Lastly, you may see some degenerate or toxic neutrophils where they are hyper-segmented. You don't get the left shift with band cells that we would see with an infectious liver disease.

I hope this helps, let me know if you have any other questions.

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Customer: replied 4 years ago.

Hello Dr. Gary,


Thanks very much this is helpful I will take a look at the books you've recommended.


Thanks again and have a good week end.