Have Medical Questions? Ask a Doctor Online!

Ask a Doctor, Get an Answer ASAP!

Midodrine Side Effects

Midodrine hydrochloride is the generic form of the vasopressor and antihypertensive tablet known as Proamatine. Midodrine is used to stabilize low blood pressure, a condition otherwise known as orthostatic hypotension. Using Midodrine hydrochloride causes stimulation to the nerve endings, which maintains blood pressure by making the blood vessels constrict. Midodrine hydrochloride is a prescription only medication.

Midodrine hydrochloride can also cause significant side effects if used in the wrong patients, or taken in the wrong doses. Read below to learn more about the side effects of Midodrine.

Midodrine hydrochloride side effects

The side effects associated with midodrine range from mild to severe depending on the person’s tolerance. A majority of side effects may not warrant concern; however, some side effects can become severe. Never take side effects lightly, consult a medical Expert if you experience any of the following.

Common side effects

  • Unusual sensations of the scalp such as itchiness, tingling or burning
  • Goosebumps or chills
  • Frequent  or troubles urinating
  • Upset stomach or abdominal pain.

Less common side effects

  • Headache
  • Nervousness or anxiety
  • Feeling mixed up or confused
  • Increased thirst or dry mouth
  • Reddening of the face, neck or chest
  • Skin irritation or rash

Serious to severe side effects

  • Blurred vision
  • Pounding in the ears and head
  • Rapid, slow or irregular heartbeat
  • Confusion

Rare side effects

  • Back pain
  • Lip sores
  • Fainting spells
  • Sleepiness
  • Dry or sensitive skin
  • Muscle cramping
  • Upset stomach, gas or heartburn
  • Vision problems

Midodrine hydrochloride special precautions

Always inform your doctor of any known allergies. Seek immediate attention if you experience any of the following allergic reactions:

  • Itchiness of the skin or rash
  • Swelling of the face, throat, tongue or lips
  • Difficulty breathing
  • Severe dizziness

Tell your doctor if you have any health problems. Make sure you tell your doctor of any alcohol or tobacco use, as drinking or smoking may hinder the effects of this medicine. Midodrine hydrochloride may cause dizziness when you stand up, or while sitting and laying down. Alcohol use may intensify these effects. Do not operate a vehicle or heavy equipment, or engage in activities that require vigilance, as this drug can alter your vision and mental focus.

Do not use Midodrine hydrochloride if you have the following medical conditions an enlarged prostate, high blood pressure (hypertension), thyroid disease or severe hyperthyroidism, pheochromocytoma or urinary problems.

Inform your health provider if you have a medical history of heart problems, liver or kidney disease, or if you have diabetes. Tell your doctor if you are on Midodrine before undergoing surgery, to avoid potential surgical complications.

Do not take Midodrine if you are pregnant or breastfeeding, as this medicine may cause harm to the unborn fetus and may pass through breast milk.

Certain conditions should be routinely monitored to see how well the medication is working. You should check your blood pressure often, and in all positions, such as sitting, standing, and lying down. If your blood pressure seems to rise while lying flat, consider elevating your head and shoulders.

Your medical provider should do routine metabolic testing of your kidney and liver functions to monitor the effects of this drug on your body.

Drug interactions

Certain over-the-counter and prescription drugs may affect the way Midodrine works. Inform your healthcare provider if you are taking any of the following medications.

  • Alpha-adrenergic blocker – Uroxatral, Cardura, Hylorel, Minipress or Hytrin
  • Tambocor, Lanoxin, Glucophage, Dyrenium, Dyazide, Maxzide or Florinef
  • Heartburn drugs – Tagamet, Tagamet HB, Zantac or Zantac 75
  • Derivatives of Quinidine such as Quinidex, Quinaglute or Quin-Release
  • Procainamide medications like Quinaglute, Procan SR, Pronestyl

This is not a complete list. Always provide your doctor a complete list of any medications you are taking so he or she can determine the best choice for you. Ask your doctor before taking any medication because some ingredients might increase your blood pressure.

Overdosing of Midodrine

Seek immediate medical attention if you suspect you or a loved one has overdosed on Midodrine Hydrochloride and contact poison control.

What if you miss a dose of Midodrine

To avoid missing a dose, always take your Midodrine medication at the same time every day. Never take a double dose. If you miss a dose within a reasonable period of the original dosing schedule, you can take it without worry. However, if you remember a missed dose an hour or two after your dosing time, wait until the next scheduled time.

The content in this article is meant for informational purposes only; it is not intended to substitute the instructions or advice of Healthcare Experts. Ask a healthcare Expert for more information on any medications you are taking.

Please type your question in the field below

5 verified Doctors are online now

Doctors on JustAnswer are verified through an extensive 8-step process including screening of licenses, certifications, education and/or employment. Learn more

Family Physician


Doctoral Degree

2592 positive reviews
Dr. Ketch

Board Certified Physician

MD, Medical Doctor

76 positive reviews

Board Certified Physician

50724 positive reviews
See all Doctors
JustAnswer in the news:
Ask-a-doc Web sites: If you've got a quick question, you can try to get an answer from sites that say they have various specialists on hand to give quick answers... seen a spike since October in legal questions from readers about layoffs, unemployment and severance.
Traffic on JustAnswer rose 14 percent...and had nearly 400,000 page views in 30 days...inquiries related to stress, high blood pressure, drinking and heart pain jumped 33 percent.
I will tell you that...the things you have to go through to be an Expert are quite rigorous.
Web sites like
...leave nothing to chance.
Tory Johnson, GMA Workplace Contributor, discusses work-from-home jobs, such as JustAnswer in which verified Experts answer people’s questions.