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What is Celestone Soluspan?

Celestone Soluspan, only obtained by prescription, is an injectable suspension that is used to treat severe inflammation caused by certain conditions, including severe asthma, severe allergies, rheumatoid arthritis, ulcerative colitis, certain blood disorders, lupus, multiple sclerosis, and certain eye and skin conditions.

Celestone Soluspan stimulates the synthesis of enzymes needed to decrease the inflammatory response. It is a time released corticosteroid that is used for its anti-inflammatory effects. It may be used for certain types of cancer for interventional pain.

Celestone Soluspan uses

Celestone Soluspan injections are used most often when anti-inflammatory effects cannot be attained with oral medication. Conditions that this injectable suspension may be indicated for include, but are not limited to

  • Allergic reactions such as contact and atopic dermatitis, hypersensitivity, perennial or seasonal rhinitis, serum sickness or inflammatory reactions to blood transfusions.
  • Skin conditions like dermatitis, herpetiformis, pemphigus and multiform Steven-Johnson’s Syndrome.
  • Gastrointestinal problems due to ulcerative colitis and regional enteritis among others.
  • Nervous system inflammation caused from cerebral edema or multiple sclerosis.
  • Leukemia and lymphoma management.
  • Renal conditions associated with lupus.

Celestone Soluspan side effects

In some instances, Celestone Soluspan may cause moderate to severe side effects. Many side effects depend on the dosage and how long the medication is meant to stay in the body. Adverse effects tend to occur less frequently in cases where a lower dose is indicated.

Common side effects

The most common side effects include increased hunger, infection at the injection site, high blood pressure, difficulty sleeping, and acid reflux.

Rare or infrequent side effects

Rarely, complications may include delayed site healing, intestinal bleeding, diabetes, fluid retention or a drop in potassium levels. Other rare side effects that occur involve confusion or depression, mood and personality changes, headache and seizures and muscle pain or weakness. This is not a complete list of side effects, since Celestone Soluspan may not provoke the same response in everyone.

Celestone Soluspan dosage information

Your Celestone Soluspan dosage should first be discussed with the prescribing physician. A pamphlet with detailed instructions is usually provided by the pharmacist. Do not use this medicine without professional dosage information, because each patient may require a different dosage strength.

Each mL of Celestone Soluspan Injectable Suspension contains: 3.0 mg betamethasone as betamethasone sodium phosphate, 3.0 mg betamethasone acetate, 7.1 mg dibasic sodium phosphate, 3.4 mg monobasic sodium phosphate, 0.1 mg edentate disodium, and 0.2 mg benzalkonium chloride. It is a sterile aqueous suspension with a pH between 6.8 and 7.2. This is a 5mL multi-dose vial.

Celestone Soluspan interactions

Tell your doctor of any medications you are taking, since they may interfere with the way Celestone Soluspan is meant to work. Drugs that interact negatively with Celestone Soluspan may include, but are not limited to

  • Antibiotics and diabetic medications
  • Diuretics
  • Contraceptives
  • Anti-inflammatory drugs
  • Ketoconazole, an antifungal medication
  • Cyclosporine, an immunosuppressant
  • Digitalis

Warnings and contraindications

Celestone Soluspan should not be used in patients who have had a hypertensive reaction to corticosteroids or in those who currently have a viral or bacterial infection. In some of these cases, doctors may use this medicine in life or death situations where the benefits far outweigh the risks.

Caution may be needed when using this medicine in patients with renal disease, diabetes mellitus, cirrhosis, diverticulitis, thromboembolic disorders and those with seizures. Also, take precaution if you have the following myasthenia gravis, heart failure, tuberculosis or ocular herpes simplex.

During trials, Celestone Soluspan showed some adverse effect on the fetuses of laboratory animals. Celestone medication may also pass through the breast milk of mothers to infants. Therefore, doctors may only decide to prescribe this medication to pregnant or breastfeeding mothers when the benefits clearly outweigh the risks. 

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