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Dr. Bridget
Dr. Bridget, Pharmacist
Category: Pharmacy
Satisfied Customers: 1011
Experience:  Clinical Geriatric Pharmacist; Pharmacy Practice Residency training with extensive knowledge in pharmacological treatment of diseases;Special interest in alternative remedies.
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Recently my 79-yrs-old mum has been put on anti-TB forecox

Customer Question

recently my 79-yrs-old mum has been put on anti-TB forecox trac 3 tablets a day for skin-tb. this anti-tb drugs decreased the hypertension drugs leading to emergency shock..
before anti-tb drugs, her bp is stable by amlodipine 10mg, losartan 100mg, HCT 25mg and concor 5mg (as she ever have heart bypass 15 yrs ago),aspirin 75mg.
after anti-tb forecox trac, her bp uncontrolled. dr changed to exforge hct , trantalol 100mg x 3 daily.
what is best for my mum as trantalol seems is very old drug n side effect not very good. can change trantalol to any other ?
Submitted: 4 months ago.
Category: Pharmacy
Expert:  Dr. Bridget replied 4 months ago.

Thanks for your question! You're speaking with Dr. Bridget. I appreciate your patience as I review your question and prepare my response.

Expert:  Dr. Bridget replied 4 months ago.

Hi Brigid! (Love your name:))

So she was on Amlodipine (calcium channel blocker), Losartan (angiotensin receptor blocker), and Concor (beta blocker).

Now she takes Exforge HCT (calcium channel blocker, angiotensin receptor blocker, diuretic combination) and Trantolol (beta blocker).

The regimen she is on now is nearly identical to her previous regimen, except the addition of a diuretic.

Trantolol is very similar to the Concor she was previously taking. These are both beta blockers. Side effects are similar, but if she wants to avoid beta blockers altogether, her doctor may consider alternatives like Clonidine, Hydralazine or an alpha blocker (terazosin, doxazosin, etc).

Do you have further questions? I am happy to help:)

Dr. Bridget

Customer: replied 4 months ago.
previously also got the diruetics.
trantalol also beta blocker , but safe to use it high dosage ?alpha blocker any help in heart ?seems there is serious interaction between anti-tb forecox trac with hypertension drugs. how to minimise the interaction ?
the anti tb drugs, adverse side effect to liver, hypertension, harsh. so I put her on milk thistle for liver, vit b6, magnesium aspartame, NAC, selenium. my main concern is always her bp. anything can help to achieve better bp ?
Expert:  Dr. Bridget replied 4 months ago.

Oh, yes...I see she did have HCTZ before:)

Trantolol (atenolol) is a beta blocker and the max dose in the US is 200 mg/day.

Alpha blockers are good for treating high blood pressure.

Anti-tb forecox trac is not known to increase blood pressure.

So her doctor switched her to another BP regimen that is basically the same...not sure why as using the same drugs will not bring the BP down. Increasing doses may. Adding an additional BP drug (like those I mentioned) would be the only way to bring her BP down (as long as there have been no other changes in her, exercise, weight, etc).

Customer: replied 4 months ago.
i did search thoroughly online , the isonaizd & rifampin of anti-TB interaction with HPT drugs.
and many rushed to emergency due to bp up when taking TB drugs.
so what do u suggest by adding additional type of bp drug ? my mum already 79 years old.
Customer: replied 4 months ago.
thats why lot ppl quit TB drug due to its adverse side effect.
even food with tyramine , will interact with TB drugs and cause massive increase in bp.
i m not a doctor, so what the doctor prescribed for mum, just follow accordingly.
but it doesnt seem helpful to my mum bp.. so i really hope u can help my mum.
Customer: replied 4 months ago.
i still waiting for answer please please please