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Dr. Sheldon
Dr. Sheldon, Pharm.D.
Category: Pharmacy
Satisfied Customers: 210
Experience:  Pharmacist
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What if any interaction is know between Imbrutinib and

Customer Question

What if any interaction is know between Imbrutinib and Tacrolimus? Thanks
Submitted: 1 year ago.
Category: Pharmacy
Expert:  Dr. C. Rollins replied 1 year ago.

There are no know drug interactions between Imbrutinib and Tacrolimus. Hopefully this fully answers your question. Once satisfied please rate my answer. Thanks.

Customer: replied 1 year ago.
Not so! One will increase the strength of the other one, butI don't know which one.
Expert:  Dr. C. Rollins replied 1 year ago.

No interactions reported in the literature found in Medi-Span dataInformation on possible theoretical interactions for Imbruvica Oral and Tacrolimus Oral , go to the individual drug monograph.

The above is from a database used by all pharmacies across the united states to check for drug interactions.

Expert:  Dr. C. Rollins replied 1 year ago.

This is a theoretical interaction that is for topical Tacrolimus, but not proven in clinical trials.

Tacrolimus (Topical) may enhance the adverse/toxic effect of Immunosuppressants. Avoid combination

Expert:  Dr. Sheldon replied 1 year ago.
Tacrolimus level will go up
Expert:  Dr. Sheldon replied 1 year ago.
Ibrutinib inhibits the metabolism of Tacrolimus, hence raising its level
Expert:  Dr. Sheldon replied 1 year ago.
P-glycoprotein/ABCB1 Inhibitors may increase the serum concentration of P-glycoprotein/ABCB1 Substrates. P-glycoprotein inhibitors may also enhance the distribution of p-glycoprotein substrates to specific cells/tissues/organs where p-glycoprotein is present in large amounts
Expert:  Dr. Sheldon replied 1 year ago.
P-glycoprotein/ABCB1 Inhibitors (Ibrutinib) may increase the serum concentration of P-glycoprotein/ABCB1 Substrates (Tacrolimus).
Expert:  Dr. Sheldon replied 1 year ago.
Do you have any other questions? Please ask.
Expert:  Dr. Sheldon replied 1 year ago.
I strive to provide quick, accurate, and thoughtful answers to questions on topics I know well. Once fully satisfied, then please kindly rate my answer  :)Dr. Riaz, Doctor of Pharmacy