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Answered in 1 hour by:
7/4/2011
Clinical Pharmacist, Pharmacist
Category: Pharmacy
Satisfied Customers: 48
Experience: I'm a clinical pharmacist, and have completed 2 years of residency and have years of experience.
VerifiedHello -
I'm sorry to hear you've been having so many issues with these stones.
Here is the literature for topamax causing kidney stones:
A total of 32/2086 (1.5%) of adults exposed to topamax during its adjunctive epilepsy therapy development reported the occurrence of kidney stones, an incidence about 2 to 4 times greater than expected in a similar, untreated population. In the double-blind monotherapy epilepsy study, a total of 4/319 (1.3%) of adults exposed to topamax reported the occurrence of kidney stones. As in the general population, the incidence of stone formation among topamax treated patients was higher in men.
An explanation for the association of topamax and kidney stones may lie in the fact that topamax is a carbonic anhydrase inhibitor. Carbonic anhydrase inhibitors can promote stone formation by reducing urinary citrate excretion and by increasing urinary pH.
Without knowing your indication for topamax, I cannot recommend a specific agent, but there are many alternatives to using it for it's approved indications. Since you are having major side effects, I would recommend you speak with your doctor regarding other possible options instead of topamax. If you plan on staying on the topamax, I would recommend you increase your fluid (primarily water) intake greatly.
I hope this helps.
Thanks!
I'm sorry to hear you've been having so many issues with these stones.
Here is the literature for topamax causing kidney stones:
A total of 32/2086 (1.5%) of adults exposed to topamax during its adjunctive epilepsy therapy development reported the occurrence of kidney stones, an incidence about 2 to 4 times greater than expected in a similar, untreated population. In the double-blind monotherapy epilepsy study, a total of 4/319 (1.3%) of adults exposed to topamax reported the occurrence of kidney stones. As in the general population, the incidence of stone formation among topamax treated patients was higher in men.
An explanation for the association of topamax and kidney stones may lie in the fact that topamax is a carbonic anhydrase inhibitor. Carbonic anhydrase inhibitors can promote stone formation by reducing urinary citrate excretion and by increasing urinary pH.
Without knowing your indication for topamax, I cannot recommend a specific agent, but there are many alternatives to using it for it's approved indications. Since you are having major side effects, I would recommend you speak with your doctor regarding other possible options instead of topamax. If you plan on staying on the topamax, I would recommend you increase your fluid (primarily water) intake greatly.
I hope this helps.
Thanks!
Clinical Pharmacist, Pharmacist
Category: Pharmacy
Satisfied Customers: 48
Experience: I'm a clinical pharmacist, and have completed 2 years of residency and have years of experience.
VerifiedClinical Pharmacist and 87 other Pharmacy Specialists are ready to help you
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