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Hi. My name is***** Thank you for your question. If you don't want a litter of puppies from this breeding, the best thing to do is to get her to your vet to have her spayed. She can easily and safely be spayed at this time (even if she is pregnant). This is pretty much the only thing that can be done to not have puppies if the breeding was successful. I would also recommending having the male neutered as that will help him to be more calm and less interested in marking territory as he gets older. It will also decrease his chances of prostate cancer and other issues with it.