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Greetings, I’m Dr. Peck, a small animal veterinarian in general practice. Hopefully I might be of some help. One moment while I reply…
Disclaimer: This communication is for discussion purposes only. Without seeing an animal in person, a valid veterinary-client-patient relationship does not exist, and therefore I am unable to diagnose, prognose, or treat. Any comments made during discussion here are based on the information provided and are simply my thoughts regarding what I’d be considering were this type of case presented to me in person. The BEST recommendation for ANY veterinary-related concern is to seek veterinary assessment in person with your local veterinarian.
Can you confirm with me the active ingredient listed on the product label?
Ok. Just wanted to make sure, that is what I was finding for this rodent bait as well.
Did you successfully induce vomiting? Did the piece of rodent bait come up?
Good. Do you have access to activated charcoal at this time? Vitamin K is not necessary for this rodenticide, it works in a different way.
Bromethalin is not an anticoagulant rodenticide as many are - it doesn't cause clotting issues from inhibiting vitamin K depending clotting factors - so vitamin K supplementation is not beneficial. There is no antidote for this toxin.
Bromethalin is a neurotoxin that causes cerebral edema (swelling in the brain) and neurologic signs. Treatment is aimed at decontamination by inducing vomiting and preventing absorption by repeated doses of activated charcoal for 2-4 days. Best recommendation is for close monitoring for neurologic signs and treating symptomatically in a hospital setting. Signs can be delayed and are dose dependent.
Minimum oral toxic dose in dogs is listed as 2.5mg/kg in my toxicology reference. Let me do some calculations based on a 60lb dog...
I'm finding 2.84mg of bromethalin per ounce cube for this bait.
60lbs = 27.27kg
2.84mg / 27.27kg = 0.1mg/kg
According to my reference at least 2.5mg/kg oral dose is necessary typically for toxicity to occur. I've found another source citing doses below 1.5mg/kg as not being associated with clinical signs. While yet another reports deaths at doses as low as 0.95mg/kg. All of these sources are stating much higher doses than the calculated 0.1mg/kg for your pup. I think your chances for no clinical signs are very good. If able, you should confirm on the packaging that the cube ingested was 1 ounce and 2.84mg is present per ounce / cube to confirm this dosage ingested.
With any ingestion of this toxin, I'd suggest administering activated charcoal at 1-4 g/kg every 8 hours for at least 2 days to be safe. Thats 30 to 120g by mouth every 8 hours (three times daily) for 2-4 days. Monitoring very closely is indicated in these situations and urgent veterinary assessment should be pursued should any clinical signs arise (weakness, balance issues, hindlimb paralysis, depression).
On the aggressive side, emergency assessment could be pursued although clinical signs with this toxicity are often delayed. Activated charcoal could be administered in clinic with close monitoring by the veterinarian and their support staff for any neurologic changes. If derangements are noted, treatment can then be instituted immediately.
Let me know if you have any follow-up questions, simply write me back! Otherwise, please be sure to kindly rate using the stars, so that I receive credit for helping with your question today (this is how professionals on this site are compensated for their time). Thanks! – Dr. Peck.
That is the same as what I'm finding - 0.01% active ingedient, which comes out to 2.84mg bromethalin per ounce of bait, with each "cube" being 1 oz.
You're very welcome. Thanks for rating!