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It sounds to me like Romeo is having an allergic or immune reaction to the vaccine. This can happen with dogs who may be older or have other health issues going on, just like with Romeo.
If this were me, I'd give your regular vet a call this morning and tell them what is going on. They may want to take a peek at him to make sure that his system isn't too stressed out, or that his organs haven't been compromised with this reaction. A little blood work will give your vet all the answers they need.They may want to get him on some IV fluids to help flush his system and may want to keep an eye on him for the day, but usually with some fluids and possibly an antihistamine the dogs do really well.I hope this helps.
Sometimes they need something a little stronger, or may need a shot of a steroid to go along with the IV fluids. The Benadryl was a good first step, but sometimes they need something a little more powerful.
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