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Ask Dr. Michael Salkin Your Own Question
Dr. Michael Salkin
Dr. Michael Salkin, Veterinarian
Category: Dog
Satisfied Customers: 28439
Experience:  University of California at Davis graduate veterinarian with 45 years of experience
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Puppy with muscle weakness started age of 4months large

Customer Question

Puppy with muscle weakness started age of 4months large breed labs negative back xrays negative more weakness front legs wheight 48pounds spinal fluid negative eating well no vomiting tick diseases profile negative toxoplasmosis and neiseria negative. Hemocanis positive treated with doxycycline.
Submitted: 1 year ago.
Category: Dog
Expert:  Dr. Michael Salkin replied 1 year ago.

Can you tell me, please, if his lab work contained an acetylcholine receptor antibody test for myasthenia gravis? Is Claro's weakness exacerbated by exercise? Is Claro under the care of a specialist internist? Where do you live that Hemocanis (Mycoplasma haemocanis) was diagnosed?

Customer: replied 1 year ago.
Is. Seen vet specialized all labs sended to univ of colorado puppy came from florida the test was performed came negative puppy has none mobility. I live in puerto rico heart worm negsative fecal negative the symptoms appeared month after arriving from palataka florida rural town
Expert:  Dr. Michael Salkin replied 1 year ago.

Thank you for the additional information. Are you seeing any improvement with the dexamethasone injections?

Customer: replied 1 year ago.
Second shot today I will. wait for third shot and see if any improvement he os taking physical terapy by a vet specialist no omprovement do far
Expert:  Dr. Michael Salkin replied 1 year ago.

A steroid such as dexamethasone is indicated when there is an inadequate response to anticholinesterase medication (pyridostigmine) when addressing myasthenia gravis. The acetylcholine receptor antibody test is the gold standard for the diagnosis of myasthenia gravis and is 98% accurate and so if Claro already tested negative, myasthenia gravis isn't likely. Claro has tested negative for the two most common central nervous system infections - toxoplasmosis and neosporosis (Neisseria?) - and cerebrospinal fluid analysis was normal and so a congenital (present at birth) brain or spinal cord disorder would be most likely. I don't believe that MRI is available for dogs where you live but that's the only diagnostic I could recommend at this time.

Customer: replied 1 year ago.
we have mri for dogs but the cost is $1300 allready spended over $3000. In labs and treatment
Expert:  Dr. Michael Salkin replied 1 year ago.

Ouch! I regret that I've offered up all that I have. I'll opt out and perhaps another expert can offer other ideas.

Customer: replied 1 year ago.
Neospora caninun negative
Customer: replied 1 year ago.
Distenper negative
Expert:  Dr. Michael Salkin replied 1 year ago.

Thank you for the clarification.