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Ask Dr. Michael Salkin Your Own Question
Dr. Michael Salkin
Dr. Michael Salkin, Veterinarian
Category: Dog
Satisfied Customers: 30380
Experience:  University of California at Davis graduate veterinarian with 45 years of experience
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I have a friend whose austrailian shepherd has had a chloramphenicol

Customer Question

I have a friend whose austrailian shepherd has had a chloramphenicol OD and is fading...nothing is working...HELP
PLEASE
Submitted: 2 years ago.
Category: Dog
Expert:  Dr. Michael Salkin replied 2 years ago.
I'm sorry that your question wasn't answered in a timely manner. While the toxicity of chloramphenicol in humans has been greatly discussed, the drug is generally considered to have a low order of toxicity in adult companion animals when appropriately dosed. However, a recent retrospective review found that 53% of 51 dogs treated with chloramphenicol at usual dosages (approx. 50 mg/kg = 22.7 mg/lb) developed adverse effects that included GI signs, lethargy, shaking, and increased liver enzymes. Anemia, panting, and aggression were reported in individual dogs. Development of aplastic anemia reported in humans, does not appear to be a significant problem for veterinary patients; however, a dose-related bone marrow suppression (reversible) is seen in all species, primarily with long-term therapy. Other adverse effects that may be noted include anorexia, vomiting, diarrhea, and depression. Can you please tell me which symptoms Roxy has demonstrated? Do you know what dose and for how long that dose was administered?
Expert:  Dr. Michael Salkin replied 2 years ago.
Hi,

I'm just following up on our conversation about Roxy. How is everything going?

Dr. Michael Salkin