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Dr. Gary
Dr. Gary, Dog Veterinarian
Category: Dog
Satisfied Customers: 3023
Experience:  DVM, Emergency Veterinarian; BS (Physiology) Michigan State Univ
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Our dog was rx'd Novox 100mg 2x daily suspected torn

Customer Question

Our dog was rx'd Novox 100mg 2x daily for a suspected torn acl. We did this for about 5 weeks. He started peeing on our carpet (an it was alot!) He now pees on the floor all the time and cannot drink enough water. We called the vet and asked if this was a side effect of the meds and they said no. Which is obviously not true. What should be do? We are now giving him all the water he wants, we were limiting it b4 to stop the relieving in the house but think he needs to flush this all out. Help! He is a mutt mix, husky, lab etc.....and weighs about 80-100lbs
Submitted: 2 years ago.
Category: Dog
Expert:  Dr. Michael Salkin replied 2 years ago.
Although uncommon, adverse effects with carprofen (Novox) including hepatocellular damage and/or renal disease have been reported. Both can cause the polydipsia (increased thirst) and polyuria (increased volume of urine) which you're currently seeing. It's essential that you determine which organ has been effected or if another disorder has arisen. For example, polydipsia and polyuria can arise from not only hepatic and renal insufficiency but also urinary tract infection involving the kidneys, diabetes mellitus and Cushings disease (both of which would also cause polyphagia - increased hunger), hypercalcemia (increased serum calcium levels), hypokalemia and hyponatremia (decreased potassium and sodium levels, respectively), Addison's disease, diabetes insipidus (rare), and brain tumor involving the hypothalamus. Please have a senior/geriatric diagnostic panel of blood and urine tests performed at your earliest convenience. Remember to fast Buddy for at least 4 hours prior to a blood draw for the most accurate test results. Please respond with further questions or concerns if you wish.