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ERAnimalNurse, Emergency Critical Care Nurse
Category: Dog
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Experience:  16+ years of veterinary experience
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My dog is on 3 anti-seizure meds 5 times a day and has been

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My dog is on 3 anti-seizure meds 5 times a day and has been for over 3 years. She is now leaking and it stinks. lt's becoming more often than not. She has excessive thirst and hunger, hind end weakness, and is over weight. She is 8 years old. She gets 2000 mg Pot Bromide, 1600mg Keppra and 100mg Pheno, (just reduced) a day. My vet is out of town until next week. Had her blood checked in July and everything seemed fine. Made a mistake with the Keppra, she gets 2250 mg a day.....



I am sorry Maddie is having trouble.


Is she leaking urine or feces?


Does this happen mainly when she is sleeping?


Does she still ask to go outside to potty? Is she able to posture normally?


Any breakthrough seizures?


Are you seeing any blood in the urine?


Is Maddie spayed?


Let me know and I will try to help.

Customer: replied 3 years ago.

l'm guessing it's urine.

Yes, only when she's sleeping. (Which is a lot)

Goes out all the time to go potty. Never has messed in the house before. Her squatting to urinate has changed due to the weakness in her rear/hips.

She had a 3 minute seizure Oct 14th, this time she did not urinate.

Haven't seen blood......but it stinks bad when she leaks and her vaginal area is brown. We clean it with babywipes.

She was spayed when she was 3-6 months?

Made a mistake with the amount of Keppra she gets. She gets 750 mg 3x a day. 2250mg a day. Really debating whether or not it's time to put her down.

Thank you for the additional information. I can tell that you are pretty worried about her, and that you are not really sure what the best course of action for her would be. The urinary incontinence might be something that can be managed, depending on the cause. Some female dogs develop something that is called Spayed female urinary incontinence. This is basically what you are describing, and can occur anywhere from age 3 on up. My own dog was diagnosed last year (she's 7) and she is well managed with no further accidents with medication. See the following website for more information on this condition.


The following website gives you more information on the medication I mentioned that my dog is taking. It is called Proin.


As the links above will tell you, it is also possible that your dog has a urinary tract infection which is related to the incontinence issues. The strong smell you note can indicate an infection. The brown staining you see around her genital area is usually indicative of excessive grooming (pigments in the saliva stain the fur). Please see the following website for more information on urinary infections.


Other possibilities include a secondary illness, which could also be responsible for the rear limb weakness, increase in water consumption and hunger. There are several illnesses that have these symptoms, some more commonly result in infections of the bladder. Some possibilities include: Diabetes.


Diabetic ketoacidosis:






Kidney disease:


The above is meant to inform you and not alarm you. Your dog might not have any of these issues. She may be easily managed with one additional medication. I think it would be a good idea to have your vet take a look at her and maybe run some tests. I realize that her labs were run n July and all was pretty normal, but it is months later and this time frame can bring significant health changes for a dog, and the incontinence can certainly indicate changes have occurred. Based on the history you provided, a urinalysis and basic panel to check kidneys, glucose levels, thyroid etc can help rule out many of the above problems. If the incontinence is the main consideration for euthanasia (meaning if she has good quality of life otherwise) then it may not be time. You know her best and can discuss your concerns frankly with your vet. If he or she is out of town all week, I think it would be best to have your dog seen by another vet, preferable at the same practice. I do not think waiting too long is a good idea, because we are not sure what exactly is going on, and once you start seeing symptoms things can quickly worsen. I hope this information is helpful to you, and that Maddie has nothing too serious going on. Please let me know if you have any further questions. Good luck with your baby.

ERAnimalNurse and other Dog Specialists are ready to help you
Hi Jill,

I'm just following up on our conversation about Maddie. How is everything going?

Customer: replied 3 years ago.

Still the same. We have an appt. Friday to see what we are going to do. lt's just so hard to see my once very active thin Maddie who now just lays around, limps, and very over weight. Her odor is fowl. l'm not so sure she isn't being over medicated. Lately she doesn't even get excited when my husband comes home. l watch her everyday go down hill. l jump every time she moves for fear of a seizure. She had a cluster over 3 years ago. lt was horrible. And l've been thinking about that posture question you asked. She does not hold her up. Her head stays down. l have a lot of questions for our vet. l've been researching all the side effects of her meds that she takes. Her quality of life sucks. She doesn't even play ball anymore. Some days are better than others, but they are far and few between. She only gets excited now when it's time for her to eat. l guess when that stops, it's time. l just don't want her to suffer. We chose when she was at the emergency vet for a week with the cluster, not to have an MRI or CTScan. Thanks for asking.

I am sorry that Maddie is not feeling well. I know how agonizing it can be to watch your baby age, and slow down, and be faced with the decision of what to do. So much uncertainty, because you want to prevent suffering and make the best choices at the best times. Trust in yourself, you know Maddie best. If you feel like she is doing worse, or if you feel like her quality of life is not good, it's time to consider euthanasia. I am so sorry to say that, especially in this context, where it is a glaring, ugly word. Please know that I am not trying to be cruel, or unfeeling or unsympathetic. I just want to validate your feelings and give you some sort of support around this decision. It's obvious how much you love her, take comfort in knowing that she is aware of it as well, and that she loves you too.


I'll keep you and Maddie in my thoughts.