PROFENDER topical solution by Bayer for cats is a combination of emodepside and praziquantel. It is indicated for the control of hookworm, roundworm and tapeworm.
The new animal drug application has some toxicology data on the oral use and can be found at http://www.fda.gov/cvm/FOI/141-275o062907.pdf.
The study used 16 cats (8 treated with the product and 8 treated with the liquid in which the drug is dissolved) and looked at food consumption, body weight, blood parameters and physical signs. After oral dosing of a topical dose, all cats salivated and four cats, two in each group, vomited. Two to four hours after dosing, tremors (two cats), abnormal gait (one cat), and abnormal respiration (one cat) were observed in the 1X group. These clinical signs resolved without treatment. The conclusion was that oral administration of emodepside/praziquantel topical solution to cats induced salivation, vomiting, tremors, abnormal gait and abnormal respiration.
Another study using 10 times the normal dose administered topically caused similar side effects. The results of both studies are in the FDA report cited above.
The US Animal Poison Control Center phone number is(NNN) NNN-NNNN Calling your vet is always appropriate if you are concerned about your animals health including side effects of drugs.
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