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Ask DR PRABIR KUMAR DAS Your Own Question
Category: OB GYN
Satisfied Customers: 1886
Experience:  MBBS(CAL)MD(G&O)
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What do these blood test results mean: Before starting on a

Customer Question

What do these blood test results mean: Before starting on a diet and exercise plan, my wife was asked to get a blood test to help set the baseline. Although they were not among the required markers, the lab also tested for ESR and CRP - and both these
were much higher than the norm (ESR is 36mm/hr and CRP is 17.9mg/L). We are worried about what this might indicate - we read that high counts are associated with chronic inflammation - and would like to know our next steps. My wife is otherwise healthy - 61
inches and 127lbs.
Submitted: 2 years ago.
Category: OB GYN
Expert:  Dr. SH replied 2 years ago.
Thank you for your question.
If she does not have any symptoms or any othe diagnoses I would just ignore these findings.
It is only a minor finding which is not something serious.
However if she has other symptoms like aching joints or muscles then she would require further investigations for autoimmune diseases, polymyagia etc.
Let me know if you have more questions.
Kind regards
Expert:  DR PRABIR KUMAR DAS replied 2 years ago.
helloThe erythrocyte sedimentation rate (ESR) measures how fast red cells fall through a column of blood. It is an indirect index of acute-phase protein concentrations (particularly depends on the concentration of fibrinogen) and is a sensitive but nonspecific index of plasma protein changes which result from inflammation or tissue damage· The ESR is affected by haematocrit variations, red cell abnormalities (eg, sickle cells) and delay in analysis (the sample should be analysed in the laboratory within four hours). It is therefore less reliable a measurement than plasma viscosity.· It is also affected by age, sex, menstrual cycle, pregnancy and drugs (eg, steroids).· A normal ESR does not exclude organic disease. A mildly elevated ESR of 20-30 mm/hour probably doesn't mean very much in itself but above 100 mm/hour is very significant and indicates something is wrong.· High ESR: any inflammatory disorder (eg, infection, rheumatoid), tuberculosis, myocardial infarction (early response), anaemia, polymyalgia rheumatica/temporal arteritis.· Low ESR: polycythaemia, hypofibrinogenaemia, congestive cardiac failure, spherocytosis, sickle cells.· The ESR is more useful than serum CRP for diagnosis and monitoring of polymyalgia rheumatica or temporal arteritis and is more frequently elevated during relapse.· Combined use of ESR and CRP is useful in assessing the severity of acute pelvic inflammatory disease.Raised ESR is also a marker for coronary heart diseaseAn increased CRP may be due to:Inflammatory disorders - eg, inflammatory arthritis, vasculitis, Crohn's disease.Tissue injury or necrosis - eg, burns, necrosis, myocardial infarction, pulmonary embolus.Infections, especially bacterial Levels of CRP rise significantly during acute inflammation, and so can be used for to indicate the presence of significant inflammatory or infectious disease, especially in children.Low specificity may be a drawback as a biomarker of sepsis in adults, but it is commonly used to screen for early-onset sepsis in neonates.Malignancy.Tissue rejection.Little or no rise occurs in osteoarthritis, systemic lupus erythematosus (SLE), leukaemia, anaemia, polycythaemia, viral infection, ulcerative colitis, pregnancy, oestrogens or steroids.There is evidence for raised CRP being an important risk factor for atherosclerotic cardiovascular disease. High CRP levels are also associated with a poorer prognosis for patients with acute coronary syndrome. However the role of CRP in atherosclerosis is controversialCRP has also been shown to have predictive value of the development of diabetes even after adjustment for a patient's body weight.It has been claimed that the CRP increases for each symptom of the metabolic syndrome present

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