OB GYN

OB-GYN questions? Ask a gynecologist online.

Ask a Doctor,
Get an Answer ASAP!

I have a question

Customer Question
Hello I have a question...
Hello I have a question
Submitted: 3 years ago.Category: OB GYN
Ask Your Own OB GYN Question
Customer reply replied 3 years ago
My wife's genetic test came back with Trisomy 15 which is a rare translocation. This happened at 7 weeks 4 days. On 7 weeks, 1 day, the ultrasound was perfectly normal with a healthy heart beat. This has happened the 2nd time. The first miscarriage was twins also at the same time (7 weeks and 5 days). However, the genetic test of the fetal tissue was chromosome tested and it was an XY and perfectly normal. Both pregnancys was done through fertility. The first one was IVF and the second was frozen embryo.Can you advise what should be done next? We have performed most of the tests and all have been normal. We are scientists in the academic world and do understand medical jargon and developmental biology
Answered in 31 minutes by:
6/3/2015
OB GYN Doctor: Dr. Norm S., Board Certified OB/GYN replied 3 years ago
Dr. Norm S.
Dr. Norm S., Board Certified OB/GYN
Category: OB GYN
Satisfied Customers: 11,302
Experience: Over 30 years of experience in OB/GYN practice, including teaching students. Fellow of American Board of Obstetrics and Gynecology.
Verified
Hello and welcome.
I am Dr. Norm, and I look forward to helping you today.
Did the second pregnancy end in miscarriage? If so, is that how the trisomy 15 was discovered, on the miscarried tissue?
Have you and your wife been tested for the translocation? Thank you.
Ask Your Own OB GYN Question
Customer reply replied 3 years ago
it did end in fetal death. Yes, a Sequenom test was done but there was very little fetal tissue. However, I requested the raw data on the sequencing and this confirmed the trisomy 15. Right now, the tissue is being sent for FISH analyses as well.
We have not been tested for translocation but will do it.However, it is not clear why this was not detected in the first miscarriage. Typically, trisomy 15 is lethal.
OB GYN Doctor: Dr. Norm S., Board Certified OB/GYN replied 3 years ago
It wasn't detected in the first miscarriage because it wasn't there.
A translocation such as trisomy 15 may be due to the translocation occurring in the sperm or egg, or one of the parents may carry a balanced translocation in their chromosomes. As long as the translocation is balanced (no extra genetic material), the parent is usually normal.
Testing of you and your wife will determine if either of you carries a balanced translocation. Even if you do, there is still a good chance of having normal children.
If the translocation occurred in the egg or sperm, it's unlikely to occur again.
Since you're doing IVF, there is a procedure called pre-implantation genetic diagnosis that can determine whether the chromosomes are normal before implantation. I believe it's more difficult to do on frozen embryos, but I think possible. It may be something to discuss with your fertility specialist.
Any trisomy tends to end in miscarriage, but trisomy 15 will often result in a live birth. The individual tends to be retarded and with other defects, but can survive.
Ask Your Own OB GYN Question
Customer reply replied 3 years ago
Thank you, ***** ***** It is helpful to understand this process. We still have one more frozen embryo that we will attempt. She is 37 and all other tests that were done was normal with healthy values.Do you recommend any other tests to be performed or is there a check list available going forward? Do you think the FISH analyses will yied anything or is there something we should look for? Is there a PCR or sequencing assay for testing balanced translocations ? Does statistics prove whether any particular chromosome is more prone to balanced translocation than others?
OB GYN Doctor: Dr. Norm S., Board Certified OB/GYN replied 3 years ago
I don't think that the FISH analysis will yield more.
Genetic testing of you and your wife will determine whether either of you has a balanced translocation.
Some chromosomes are more prone to translocations, but I don't think that means much.
I would just discuss it with your fertility specialist. There is no check list.
Ask Your Own OB GYN Question
Was this answer helpful?

How JustAnswer works

step-image
Describe your issueThe assistant will guide you
step-image
Chat 1:1 with an ob gyn doctorLicensed Experts are available 24/7
step-image
100% satisfaction guaranteeGet all the answers you need
Ask Dr. Norm S. Your Own Question
Dr. Norm S.
Dr. Norm S.
Dr. Norm S., Board Certified OB/GYN
Category: OB GYN
Satisfied Customers: 11,302
11,302 Satisfied Customers
Experience: Over 30 years of experience in OB/GYN practice, including teaching students. Fellow of American Board of Obstetrics and Gynecology.

Dr. Norm S. is online now

A new question is answered every 9 seconds

How JustAnswer works:

  • Ask an ExpertExperts are full of valuable knowledge and are ready to help with any question. Credentials confirmed by a Fortune 500 verification firm.
  • Get a Professional AnswerVia email, text message, or notification as you wait on our site. Ask follow up questions if you need to.
  • 100% Satisfaction GuaranteeRate the answer you receive.

JustAnswer in the News:

Ask-a-doc Web sites: If you've got a quick question, you can try to get an answer from sites that say they have various specialists on hand to give quick answers... Justanswer.com.
JustAnswer.com...has seen a spike since October in legal questions from readers about layoffs, unemployment and severance.
Web sites like justanswer.com/legal
...leave nothing to chance.
Traffic on JustAnswer rose 14 percent...and had nearly 400,000 page views in 30 days...inquiries related to stress, high blood pressure, drinking and heart pain jumped 33 percent.
Tory Johnson, GMA Workplace Contributor, discusses work-from-home jobs, such as JustAnswer in which verified Experts answer people’s questions.
I will tell you that...the things you have to go through to be an Expert are quite rigorous.

What Customers are Saying:

I feel so much better today, and upon further investigation believe that there is a chance that the responses I got saved me from a serious, even life threatening situation. I am very grateful to the experts who answered me.

Susan O.USA

I can go as far as to say it could have resulted in saving my sons life and our entire family now knows what bipolar is and how to assist and understand my most wonderful son, brother and friend to all who loves him dearly. Thank you very much

Corrie MollPretoria, South Africa

I thank-you so much! It really helped to have this information and confirmation. We will watch her carefully and get her in for the examination and US right away if things do not improve. God bless you as well!

ClaudiaAlbuquerque, NM

Outstanding response time less than 6 minutes. Answered the question professionally and with a great deal of compassion.

KevinBeaverton, OR

Suggested diagnosis was what I hoped and will take this info to my doctor's appointment next week.
I feel better already! Thank you.

ElanorTracy, CA

Thank you to the Physician who answered my question today. The answer was far more informative than what I got from the Physicians I saw in person for my problem.

JulieLockesburg, AR

You have been more help than you know. I seriously don't know what my sisters situation would be today if you had not gone above and beyond just answering my questions.

John and StefanieTucson, AZ

< Previous | Next >

Meet the Experts:

Dr. C.

Dr. C.

Board Certified

2,537 satisfied customers

30 years of experience and an award-winning educator.

Monika Hearne, M.D.

Monika Hearne, M.D.

Board Certified OB/GYN

5,752 satisfied customers

With experience and compassion, I treat my patients like family.

DR PRABIR KUMAR DAS

DR PRABIR KUMAR DAS

CONSULTANT GYNAECOLOGIST

1,651 satisfied customers

MBBS(CAL)MD(G&O)

Dr.JBB

Dr.JBB

Board Certified OB/GYN

1,293 satisfied customers

15 yrs experience in Women's Health, Pelvic reconstruction and Incontinence

Dr. Lawrence

Dr. Lawrence

OB/GYN

822 satisfied customers

Board Certified OB/GYN and accomplished educator

Dr.Ashwini Joshi

Dr.Ashwini Joshi

OB/GYN (Doctor)

400 satisfied customers

Consulting Obstretician & Gynecologist

Dr C

Dr C

OB/GYN (Doctor)

367 satisfied customers

MD

< Previous | Next >

Related OB GYN Questions
What are the reasons for a delayed period besides pregnancy?
What are the reasons for a delayed period besides pregnancy? … read more
Dr. Greg
Dr. Greg
Residency
450 satisfied customers
I wanted to talk about pregnancy and implantation bleeding.
Hi, I wanted to talk about pregnancy and implantation bleeding … read more
Dr SS
Dr SS
Doctoral Degree
12,327 satisfied customers
I have a question regarding possible pregnancy or maybe a
I have a question regarding possible pregnancy or maybe a UTI … read more
Dr. Arun Phophalia
Dr. Arun Phophalia
Consultant Surgeon and Sports Medicine
Post-Doctoral Degree
33,903 satisfied customers
Well ok this a weird one i have anxiety about pregnancy. I
Hi well ok this Ian a weird one i have anxiety about pregnancy … read more
Dr. J
Dr. J
Physician, Partner
Doctoral Degree
653 satisfied customers
I recently did an ivf. I am 5 days post embryo transfert. I
I recently did an ivf. I am 5 days post embryo transfert. I took very carefully the medication that my doctor has prescribed. I am also prone to migraine. Today I took paracetamol at 7:20. I wanted to… read more
Dr Uzair
Dr Uzair
FCPS (R) General Surgery
M.B.,B.S. FCPS
3,811 satisfied customers
How will I know if I'm having a miscarriage very early on in
How will I know if I'm having a miscarriage very early on in pregnancy? … read more
Dr. Nina Lim
Dr. Nina Lim
Doctor of Medicine
572 satisfied customers
I had a miscarriage last year due to a bicornuate uterus.
Hello. I had a miscarriage last year due to a bicornuate uterus. The first obgyn advised that I had a procedure done to fix the uterus. I got a second opinion and he said the only thing that can be do… read more
Dr. J
Dr. J
Physician, Partner
Doctoral Degree
653 satisfied customers
I have a question regarding a miscarriage my wife and I just
I have a question regarding a miscarriage my wife and I just experienced … read more
Dr. Nina Lim
Dr. Nina Lim
Doctor of Medicine
572 satisfied customers
I have a question. I have had two miscarriages previously.
Hi.My name is***** have a question. I have had two miscarriages previously. One about three years ago and most recent one back in October. I am now 29 years of age almost 30. I am very concerned becau… read more
Medicaldoctor
Medicaldoctor
postgraduate resident,MD
Master\u0027s Degree
123 satisfied customers
I just took a pregnancy test a few days ago and it came back
I just took a pregnancy test a few days ago and it came back positive. I'm bleeding now and having tiny pieces of tissue come out. I think I'm miscarrying. Should I just use a pad? No fever or pain. … read more
Dr.Saleem
Dr.Saleem
Consultant Cardiologist
Doctoral Degree
839 satisfied customers
I need answer. So i recently had a miscarriage and i now
so i recently had a miscarriage and i now pregnant again. My conception date was March 19 or 20 which put me at 5 weeks. I told my OB and my blood work show that that my HCG is in the 8800. I did an ultrasound today and it show an empty sac … read more
Dr. K.
Dr. K.
Staff physician
MD
584 satisfied customers
I need answer. So i recently had a miscarriage and i now
so i recently had a miscarriage and i now pregnant again. My conception date was March 19 or 20 which put me at 5 weeks. I told my OB and my blood work show that that my HCG is in the 8800. I did an ultrasound today and it show an empty sac … read more
The Physician
The Physician
Emergency Room Physician
MSc. Pediatric Emergency Medicine, MD.
946 satisfied customers
I'm 5 weeks pregnant and I've had two previous miscarriages,
I'm 5 weeks pregnant and I've had two previous miscarriages, but I've been having a lot of cramping over the last few days but no bleeding, the cramping comes and goes. I'm just a bit worried I don't … read more
Dr. K.
Dr. K.
Staff physician
MD
584 satisfied customers
What are risks associated with hydrosaplinx and pregnancy? I
What are risks associated with hydrosaplinx and pregnancy? I am scheduled to meet with my obgyn in two weeks and just found out I'm about six weeks pregnant. Am I a higher risk? … read more
Dr Uzair
Dr Uzair
FCPS (R) General Surgery
M.B.,B.S. FCPS
3,811 satisfied customers
Can rough sex and foreplay cause miscarriage at 4 weeks 5 days pregnan
Can rough sex and foreplay cause miscarriage at 4 weeks 5 days pregnant? I spotted red blood and streaks couple of hours after sex. Then a week later miscarried. Was it because of the rough sex and fo… read more
Dr.M.D.Mazumdar
Dr.M.D.Mazumdar
Consultant Gynecologist
MBBS. MD (Obstetrics and Gynecology
3,702 satisfied customers
Can rough sex or foreplay at 5 weeks 4 days cause a embryo
Can rough sex or foreplay at 5 weeks 4 days cause a embryo to dislodge and cause a miscarriage i spotted red blood and streaked a little after the sex then miscarriage a week later… read more
Dr. K.
Dr. K.
Staff physician
MD
584 satisfied customers
My wife is going through IVF embryo transfer hopefully on
Hello. My wife is going through IVF embryo transfer hopefully on Friday. She had her period on 11/27. The MD then had her start Lupron 10mg Daily, estradiol 4mg Daily, enoxaparin 40mg daily, and aspir… read more
Dr. J
Dr. J
Physician, Partner
Doctoral Degree
653 satisfied customers
Please advise on threatened miscarriage pregnancy, baby is
please advise on threatened miscarriage pregnancy, baby is alive but water is low and shes uncomfortable… read more
Dr. J
Dr. J
Physician, Partner
Doctoral Degree
653 satisfied customers
Disclaimer: Information in questions, answers, and other posts on this site ("Posts") comes from individual users, not JustAnswer; JustAnswer is not responsible for Posts. Posts are for general information, are not intended to substitute for informed professional advice (medical, legal, veterinary, financial, etc.), or to establish a professional-client relationship. The site and services are provided "as is" with no warranty or representations by JustAnswer regarding the qualifications of Experts. To see what credentials have been verified by a third-party service, please click on the "Verified" symbol in some Experts' profiles. JustAnswer is not intended or designed for EMERGENCY questions which should be directed immediately by telephone or in-person to qualified professionals.

Disclaimer: Information in questions, answers, and other posts on this site ("Posts") comes from individual users, not JustAnswer; JustAnswer is not responsible for Posts. Posts are for general information, are not intended to substitute for informed professional advice (medical, legal, veterinary, financial, etc.), or to establish a professional-client relationship. The site and services are provided "as is" with no warranty or representations by JustAnswer regarding the qualifications of Experts. To see what credentials have been verified by a third-party service, please click on the "Verified" symbol in some Experts' profiles. JustAnswer is not intended or designed for EMERGENCY questions which should be directed immediately by telephone or in-person to qualified professionals.

Show MoreShow Less

Ask Your Question

x