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Fasciculations in healthy subjects
Fasciculations can also be found in individuals with no neurological disease. In 1963, Reed and Kurland warned that the presence of fasciculations was not necessarily a prelude to the onset of a progressive and lethal disease, due to the involvement of the lower motor neuron (ALS).
These authors, in agreement with others, concluded that physical exercise, stress, fatigue and caffeine abuse can precipitate or aggravate this picture.
Muscle fasciculation or muscle twitching is caused by minor muscle contractions in one particular area, or the persistent and uncontrolled twitching of a muscle group in a distribution of a single nerve fiber or filament. Usually they are benign and resolve on their own, but persistent flutter may need following investigations;
1) electromyography (EMG)
2) nerve conduction velocity (NCV)
3) blood electrolytes like calcium, magnesium, potassium, sodium, etc
4) thyroid and parathyroid function tests
5) blood chemistry and complete metabolic profile
The common causes can be;
1) Idiopathic; no cause is ascertained and majority falls in this group.
2) Increased caffeine intake
3) Increased alcohol intake
5) Deficiency in diet and nutrients / minerals
6) Some neurological diseases; uncommon
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