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Yes it can. Pituitary gland controls all other hormonal glands in the body. The tumor can make it induce other metabolic hormones like cortisol, growth hormone making weight loss a difficult proposition. Her cortisol, HGH levels should be checked. Also T3 is prescribed in case of thyroid hormone deficiency. T3 can boost appetite and also may interfere with weight loss. Best wishes,It was my pleasure to help you today.If I have answered all your questions, Please rate my response Excellent (click on the 5th star on top).Please bookmark my profile for fast, reliable authentic answers!This is the link to my profile:http://www.justanswer.com/medical/expert-mysticdoc/