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Hello,I am Dr. Aren and I will help with your query.Pregabalin in higher doses does cause impaired memory,sleepiness,dizziness and anxiety. If taken with alcohol,it may cause confusion,ataxia ,loss of control,abnormal thinking,blurred vision or diplopia/double vision and negative thoughts.The high doses will probably not cause any permanent damage,the upper limit for Lyrica is usually 600 mgms. Occasionally it may start of a panic attack if used along with alcohol.I feel that no permanent damage would have been caused,but intermixing of the two should be avoided as a rule.
Alcohol binges and use of high doses of pregabalin may cause amnesia for a short while(the exact no of days/weeks is debatable),but permanent damage is unlikely.
I am using Pregabalin extensively in my practice but at lower doses,it usually needs to be used for long periods like a couple of years in cases of neuropathic pain and radiculitis secondary to Intervertebral disc disease.I have yet to see a case of real amnesia,there are some cognitive problems like increased sleepiness,drowsiness,co-ordination issues and the like but they usually settle down after a couple of weeks.I do not think that high doses for such a short while will cause serious damage or problems.