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Dr. Z
Dr. Z, Psychologist
Category: Mental Health
Satisfied Customers: 10643
Experience:  Psy.D. in Clinical Forensic Psychology with a background in treating severe mental illnesses.
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I am on a 20 mg daily dose of paroxetine to help primarily

Customer Question

I am on a 20 mg daily dose of paroxetine to help primarily with anxiety and insomnia. I have read that paroxetine is quite anticholinergic--the highest of all SSRIs. Would like to try Cymbalta, and I am wondering if the anticholinergic load is less for this drug? I'm a 56 year-old menopausal woman already having memory issues. Don't want to make that any worse. Thanks for your help.
Submitted: 1 year ago.
Category: Mental Health
Expert:  Dr. Z replied 1 year ago.

*This website DOES NOT constitute treatment and only provides information and advice in a Q&A format. For treatment (therapy and/or medications) you must go to a licensed professional in your area. Please note that anything said here is not private or confidential, as this is a public forum.

Hello and thank you for using JustAnswer. The anticholinergic effects associated with Cymbalta is definitely a lot lower than the Paxil if that is your concern, but studies have shown that Effexor is considered to have less of an anticholinergic effect than Cymbalta if you wanted to try Effexor instead. Overall though the levels of anticholinergic activity with Cymbalta or Effexor is considerably low and most likely will not cause any short or long-term effects to your cognitive functions.

Customer: replied 1 year ago.
Good information. Thank you.
Expert:  Dr. Z replied 1 year ago.

You are most welcome. I wish you all the best with your continued treatment.

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