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MN Psychiatrist
MN Psychiatrist, Psychiatrist
Category: Mental Health
Satisfied Customers: 792
Experience:  Physician for 17 years, adult psychiatrist for 13 years working with a wide variety of patients.
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MY WIFE TAKES CLOZARIL IT WORKS WONDERS, VERY EXPENSIVE IF

Resolved Question:

MY WIFE TAKES CLOZARIL IT WORKS WONDERS, VERY EXPENSIVE IF SHE SWITCHES TO THE SUBSTITUTE CLOZAPIN, WHAT IS THE DIFFERENCE IN EFFECT
Submitted: 5 years ago.
Category: Mental Health
Expert:  MN Psychiatrist replied 5 years ago.
Hello, I am a psychiatrist.

To answer your question, clozapine is the generic form of Clozaril.
The FDA requires that the active ingredient (which is clozapine) be the same exact medication in both the name-brand and the generic medication. What is allowed to be different is the filler(s) in the pill, or whether it's a pill or a capsule.

That said, the FDA requires the generic medication to be absorbed into the body within 20% of as well as the name-brand medication is absorbed into the body. In other words, say that 90% of the clozapine in Clozaril is absorbed into the body. That means that the FDA would require that at least 80% of that, or 72% (80% of 90%) of the clozapine in the generic clozapine be absorbed into the body. It may be absorbed much better than that, though, and usually it doesn't make much difference clinically. If it seems to, it's possible that the dose could be raised bit to make up for the difference.

Does this make sense?
Customer: replied 5 years ago.
MY ONLY CAVEAT ISTHAT CLOZAPIN IS A SUBSTITUE, THERE IS NO GEREIC
Expert:  MN Psychiatrist replied 5 years ago.
Clozapine is the generic name for Clozaril. Clozapin is the same thing.
See here:
http://www.clozaril.com/index.jsp
http://www.rxlist.com/clozaril-drug.htm
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