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TherapistMarryAnn, Therapist
Category: Mental Health
Satisfied Customers: 5809
Experience:  Over 20 years experience specializing in anxiety, depression, drug and alcohol, and relationship issues.
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I take buspirione 45mg daily and lexapro 20mg daily. I feel

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I take buspirione 45mg daily and lexapro 20mg daily. I feel like I am more depressed than ever. I have been on many meds and combinations over the years. I am getting very frustrated and don't know where to turn....
Submitted: 5 years ago.
Category: Mental Health
Expert:  TherapistMarryAnn replied 5 years ago.

Hi, I'd like to help you with your question.

If you have been on these medications for more than two years, the effectiveness may no longer be there. After two years, SSRI's do not work. So you may either need to change the dosage or change your medication.

Considering that you have tried many medications and combinations over the years and have not found relief, you may want to consider other options. You mentioned being in therapy twice a month, but seeing a therapist weekly would be much more effective. Also, do you feel that your therapist is helping you? Finding a therapist is like finding your family doctor, it may take a few tries to find someone who is compatible and who can help. To find a therapist, talk to your doctor about a referral. Or you can search on line at This link helps you find a therapist and also provides a brief history of what the therapist does. Any Master's level or Ph.D level therapist can help you.

Also, self help is a good option. Many people find relief through answers they can find in books and on line. Here are some links to help you get started: this also has a helpful section on medications, types and options.

The Depression Cure: The 6-Step Program to Beat Depression without Drugs by Stephen S. Ilardi

Undoing Depression: What Therapy Doesn't Teach You and Medication Can't Give You by Richard O'Connor

The Cognitive Behavioral Workbook for Depression: A Step-by-step Program (Workbook) by William J. Knaus and Albert Ellis

You can find these books on or your local library may have them for you.

You may also want to consider support groups. Having others who share your experiences and have found other solutions can help tremendously in your recovery. Here are some links to help:

I hope this has helped you,

TherapistMarryAnn and other Mental Health Specialists are ready to help you
Expert:  TherapistMarryAnn replied 5 years ago.

I haven't heard from you. Did you have more questions or want clarification?


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