Topamax could help...but it usually averages less than 4% weight loss (8 pounds in a 200 pound person). The seroquel that you take is the most likely culprit for the weight gain. Here are some other ideas, but don't change anything until speaking to your own doctor 1st.
1a) Switch seroquel to similar medicine like geodon or abilify; these 2 don't cause weight gain. There is no guarantee whether either of these meds will work as good as the seroquel for you personally. It could go either way.
1b) Switch to a medicine like risperdal, haldol, fluphenazine...these can have weight gain, but less than seroquel on average. The last 2 are more likely to cause tardive dyskinesia with long term use, esp. at high doses. Avoid zyprexa or clozaril as these 2 can have just as much or more weight gain than seroquel.
2) Try a lower dose of seroquel; however, recent studies have shown that even low doses of seroquel can contribute to weight gain.
3) brainstorm for other ideas with your doctor
4) If you're feeling good overall emotionally & mentally, you could opt to learn to accept the weight gain. Our culture is somewhat brainwashed to think people need to be excessively thin...borderline anorexic. Make sure you have a realistic body image and to love yourself as a person...the inner beauty.
I hope this helps. Take care.
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