Mental Health

Have Mental Health Questions? Ask a Psychiatrist Online

Ask an Expert,
Get an Answer ASAP!

Mental Health

After nine years of continuous use of Stablon® (Tianeptine)

Customer Question
at 3X, 12.5 mg it...
After nine years of continuous use of Stablon® (Tianeptine) at 3X, 12.5 mg it became progressively less effective. Especially in the enigmatic Neuroenhancing/Stimulant instant effect it has for some patients, as was my case. Can you tell me of a way of augmenting the effect?
Submitted: 8 years ago.Category: Mental Health
Show More
Show Less
Ask Your Own Mental Health Question
Answered in 16 hours by:
5/3/2009
Mental Health Professional: Dr. Kaushik, Psychiatrist replied 8 years ago
Dr. Kaushik
Dr. Kaushik, Psychiatrist
Category: Mental Health
Satisfied Customers: 4,688
Experience: MD Psychiatry
Verified
Hi there,

Welcome to Just answer !

Well, it seems that your body has developed resistance against stablon , an ssre , which acts as an antidepressant, mood brightner , and a non sedative anxiolytic as well, since you have been using this drug since quite a long time , and this kind of drug resistance is quite common.

So, i would like to ask you a few questions , which i expect you to answer against their numbers .

1) What are your present symptoms now that stablon is working less effectively?

2) How open are you in tryng a new drug / drugs , since the current drug that you are taking , stablon , is no longer effective and being the only one in its class of SSRE , we do not have any other option but to try a new type of anti depressant , also keeping in mind that you have already tried TCAs , SSRIs , MAOi?

3) Have you been ever placed on SNRI anti depressants ?

Regards...
Ask Your Own Mental Health Question
Customer reply replied 8 years ago
1) 3X, 12.5mg taken together, since Dec 2000, no longer are enough. Taken upon awakening they had an effect in 45 minutes. They would remove all depression and the strong sickness behavior from the inflammatory cytokines. In particular, the peculiar neuroenhancing stimulant effect it produced in me disappeared. Now it has a partial Mood Brightening and Anti-Depressant effect lasting in an hour that last only 4 hours. I need to repeat by taking one or more every 4-5 hours the rest of the day depending on how active I need to be. During its first three years it had an effect on me presumably like the one described for Ketamine.
2) I am not open to experimenting with any of the drugs available here since I just about have tried all of them and the suffering and illness they have produced is great. I left out mentioning before that I also went through an ECT series in Miami. It did not produce any effect at all, but at least did not affect my memory.
3) SNRIs! I force took Effexor for 4-1/2 months with no benefit. Had me completely incapacitated, not able to read, in bed or in a lean-to couch, TV or trouble sleep all the way.
N.B. I await the market availability of Valdoxan (agomelatine) but do not know if it will be effective. It's mode of action is different from Stablon in being an agonist at MT(1) & MT(2) receptors of the melatonergic system and putative 'rapid regulation of the sleep-wake cycle'. But it key, in my opinion, lies in its antagonistic activity at the 5-HT(2c)receptor. This would be another novel approach, different from Stablon although produced by the same pharmaceutical; Servier Laboratoires--it my not work on me. Antidepressants are sold over most the world without the need for a prescription by asking the pharmacist. That's how I get my Stablon and will soon Valdoxan, but as mentioned there is no assurance that it will work for me. Please note!! I made this consultation to search for an augmenter of Stablon that would bring it back to its former just about miraculous effectiveness. I have searched for years and have not found mention of any. However, I am not fluent in French and have been investigated in universe. To repeat, my question is about and augmenting, reinforcing. I have not heard either of any combinations but have experimented with some of my own, but to no avail.
It pleases me to share this information with you. By your picture you seem like a young fellow. The monoamine theory of depression is invalid it is only the financial interest of the big pharmaceutical that still try to keep it alive.
Write anytime, independently at***@******.***, to exchange views on theories of neurogenesis of depression. Is it an immune disease? Glial cells inflammatory citokines? No! That only produces the somatic sickness part. If this is a mind-body problems had can Ketamine (a chemical) remove depression instantly? But mind is involved, the mood part involves feelings and we can only feel in the Mind and not in the Brain.
Regards,
Al Juliao (Julian)
Mental Health Professional: Dr. Kaushik, Psychiatrist replied 8 years ago
Thanks for the elaboration. I must admit you are quite well versed with Depression and anti depressants , but since there is no other SSRE other than stablon , so i think i will not be able to help you in this regard . I would have asked you to try a combination of Milnacipran and Trazadone , for your depression , but since you are not willing to change to any new regime , so this will not work out . I will be opting out and any other expert here will be fielding your question anytime soon.

I wish you best of health. Take care ...

Regards...
Ask Your Own Mental Health Question
Customer reply replied 8 years ago

I have taken Cymbalta and Desyrel separately here are the side effects from Cymbalta medical log:

CYMBALTA SIDE EFFECTS

· Lack of libido

· Anorsgamia

· Constant dreaming

· Instant onset of dreaming

· Vivid dreams

· Lucid dreams

· Nightmares dreams

· Day sleeping (hrs)

· Somnolence (all day)

· …horrible headaches that last for days and weeks

Desyrel was not near as bad, none of the sexual things, but others. CYMBALTA was real toxic.

I just picked-up on DESYREL as antagonist to the 5-HT(2c) receptor so now there's less hope for Valdoxan--hopefully it is the 5-HP Reuptake Inhibition (SARI) part that is doing harm.

Thanks for the conversation; It came out reconfirming the facts mentioned before and the showing that doctors are still pushing the same poison. It doesn't help goodwill to be at the receiving end..., still after decades.

Bye now,

Ask Dr. Keane Your Own Question
Dr. Keane
Dr. Keane
Dr. Keane, Therapist
Category: Mental Health
Satisfied Customers: 1,379
1,379 Satisfied Customers
Experience: Clinical Psychology PhD, Licensed Professional Counselor with experience in marriage/family, teens and child psychology.

Dr. Keane is online now

A new question is answered every 9 seconds

How JustAnswer works:

  • Ask an ExpertExperts are full of valuable knowledge and are ready to help with any question. Credentials confirmed by a Fortune 500 verification firm.
  • Get a Professional AnswerVia email, text message, or notification as you wait on our site. Ask follow up questions if you need to.
  • 100% Satisfaction GuaranteeRate the answer you receive.

JustAnswer in the News:

Ask-a-doc Web sites: If you've got a quick question, you can try to get an answer from sites that say they have various specialists on hand to give quick answers... Justanswer.com.
JustAnswer.com...has seen a spike since October in legal questions from readers about layoffs, unemployment and severance.
Web sites like justanswer.com/legal
...leave nothing to chance.
Traffic on JustAnswer rose 14 percent...and had nearly 400,000 page views in 30 days...inquiries related to stress, high blood pressure, drinking and heart pain jumped 33 percent.
Tory Johnson, GMA Workplace Contributor, discusses work-from-home jobs, such as JustAnswer in which verified Experts answer people’s questions.
I will tell you that...the things you have to go through to be an Expert are quite rigorous.

What Customers are Saying:

I can go as far as to say it could have resulted in saving my sons life and our entire family now knows what bipolar is and how to assist and understand my most wonderful son, brother and friend to all who loves him dearly. Thank you very much

Corrie MollPretoria, South Africa

I thank-you so much! It really helped to have this information and confirmation. We will watch her carefully and get her in for the examination and US right away if things do not improve. God bless you as well!

ClaudiaAlbuquerque, NM

Outstanding response time less than 6 minutes. Answered the question professionally and with a great deal of compassion.

KevinBeaverton, OR

Suggested diagnosis was what I hoped and will take this info to my doctor's appointment next week.
I feel better already! Thank you.

ElanorTracy, CA

Thank you to the Physician who answered my question today. The answer was far more informative than what I got from the Physicians I saw in person for my problem.

JulieLockesburg, AR

You have been more help than you know. I seriously don't know what my sisters situation would be today if you had not gone above and beyond just answering my questions.

John and StefanieTucson, AZ

I have been dealing with an extremely serious health crisis for over three years, and one your physicians asked me more questions, gave me more answers and encouragement than a dozen different doctors who have been treating me!!

Janet VPhoenix, AZ

< Previous | Next >

Meet the Experts:

Dr. Keane

Dr. Keane

Therapist

1,379 satisfied customers

Clinical Psychology PhD, Licensed Professional Counselor with experience in marriage/family, teens and child psychology.

TherapistMarryAnn

TherapistMarryAnn

Therapist

3,984 satisfied customers

Over 20 years experience specializing in anxiety, depression, drug and alcohol, and relationship issues.

Dr. Olsen

Dr. Olsen

Psychologist

2,336 satisfied customers

PsyD Psychologist

Norman M.

Norman M.

Principal psychotherapist in private practice. Newspaper contributor, over 2000 satisfied clients on JA

2,246 satisfied customers

ADHP(NC), DEHP(NC), ECP, UKCP Registered.

Dr. Michael

Dr. Michael

Psychologist

2,177 satisfied customers

Licensed Ph.D. Clinical Health Psychology with 30 years of experience in private practive and as a clinical psychology university professor.

Steven Olsen

Steven Olsen

Therapist

1,728 satisfied customers

More than twenty years of expertise in counseling, psychological diagnosis and education

Anna

Anna

Mental Health Professional

1,656 satisfied customers

Licensed Clinical Social Worker with 29 years in addictions and mental health.

< Previous | Next >

Related Mental Health Questions
I am having terrible guilt and shame about things I did in
I am having terrible guilt and shame about things I did in my past which have suddenly come to my consciousness - when I was about 16 I was extremely sexual and ended up sniffing knickers on a number … read more
LeahMSWuofm
LeahMSWuofm
Clinical Social Worker
Master\u0027s Degree
717 satisfied customers
Ocd self doubts. I take sleeping tablets to help me sleep.
Hi Pearl, I take sleeping tablets to help me sleep. My mood is a bit depressed and I started taking medication as prescribed by my GP yesterday thanks. … read more
LeahMSWuofm
LeahMSWuofm
Clinical Social Worker
Master\u0027s Degree
717 satisfied customers
Sleeping all day, at one moment can feel on top of the
Sleeping all day, at one moment can feel on top of the world, and another time feel super sad… read more
Therapist Leslie
Therapist Leslie
Masters, Professional Psychology
5 satisfied customers
Ever since my mom died I have extreme anxiety. Sleep. Good
Ever since my mom died I have extreme anxiety JA: How long have you been dealing with this? Is there anything in particular that seems to make the symptoms better or worse? Customer: Sleep JA: Anythin… read more
JohnMichaels,MS,LPC
JohnMichaels,MS,LPC
Counselor
Master\u0027s Degree
166 satisfied customers
Was on Zoloft 200 mg for GAD and 1mg of Atavan to aid sleep.
Was on Zoloft 200 mg for GAD and 1mg of Atavan to aid sleep. Over the last few months I've steadily gained weight and I fully tapered off the medicine about 3/4 weeks ago. DUring my time on the medici… read more
Dr. Kaushik
Dr. Kaushik
Psychiatrist
4,688 satisfied customers
I have been taking .25 Ativan to sleep for seven months, due
I have been taking .25 Ativan to sleep for seven months, due to taking Levaquin, which brought on terrible anxiety and many other symtoms which were horrific. I feel I am hurting my Gaba transmitters … read more
Dr. Kaushik
Dr. Kaushik
Psychiatrist
4,688 satisfied customers
Vns-swallowing horsemeat 5 yer. It had stopped sleeping.
vns-swallowing horsemeat 5 yer JA: How is your mood? Are you experiencing regular sleep disturbances (e.g. trouble falling asleep, waking up early)? Customer: Yes it had stopped sleeping JA: Anything … read more
Dr. Phil, MD
Dr. Phil, MD
Internal Medicine Physician
Doctoral Degree
2,619 satisfied customers
I am on escitalopram 10mg....I can't sleep at night....what
Hi ...I am on escitalopram 10mg....I can't sleep at night....what is a good drug to use? … read more
LeahMSWuofm
LeahMSWuofm
Clinical Social Worker
Master\u0027s Degree
717 satisfied customers
I take Trazodone 25 (half tablet) for depression and sleep
I take Trazodone 25 (half tablet) for depression and sleep quality. Without it, I roar like a lion, yawning the next day. I have taken Prozac 40 for ten years which chases the Trazodone, for me, the n… read more
Dr. Kaushik
Dr. Kaushik
Psychiatrist
4,688 satisfied customers
I have a question regarding anti-anxiety and sleeping
I have a question regarding anti-anxiety and sleeping tablets. Can you help me with this? … read more
Linda D.
Linda D.
Master\u0027s Degree
721 satisfied customers
What should I expect to ask you? My mood is mellow, sleep
My mood is mellow, sleep disturbances are collaborative to my issues … read more
Linda D.
Linda D.
Master\u0027s Degree
721 satisfied customers
OKMH824211 I sometimes have difficulty sleeping. It's not a
OKMH824211 I sometimes have difficulty sleeping. It's not a chronic problem, but it happens often enough that I'd like to find techniques/methods that can help me when I experience the problem. I don'… read more
Dr. Phil, MD
Dr. Phil, MD
Internal Medicine Physician
Doctoral Degree
2,619 satisfied customers
I quit Klonopin 3.5 months ago, but still only sleeping 2
I quit Klonopin 3.5 months ago, but still only sleeping 2 days a week. I am completely sleep deprived and feel like I am going mad. I have tried almost every other medication for sleep to no avail. Am… read more
Dr. Phil, MD
Dr. Phil, MD
Internal Medicine Physician
Doctoral Degree
2,619 satisfied customers
I am looking for support and counselling. My sleep is fine.
Hi, my name is ***** ***** I am looking for support and counselling … read more
JohnMichaels,MS,LPC
JohnMichaels,MS,LPC
Counselor
Master\u0027s Degree
166 satisfied customers
I have had trouble sleeping for a few weeks have depression
I have had trouble sleeping for a few weeks have depression and anxiety. At 10:00pm I took my Restorial 7.75 and 1/2 tablet of Ambein 3mg I think. Still awake, any suggestions? … read more
Dr. Kaushik
Dr. Kaushik
Psychiatrist
4,688 satisfied customers
Pearl, I don't have problem sleeping. I have been diagnosed
I have been diagnosed with Bipolar with severe depressive episodes.… read more
JohnMichaels,MS,LPC
JohnMichaels,MS,LPC
Counselor
Master\u0027s Degree
166 satisfied customers
Im on 5mg esopram and it doesnt help me sleep so im
Hi im on 5mg esopram and it doesnt help me sleep so im wondering if its okay to take imovan to sleep … read more
Dr. Kaushik
Dr. Kaushik
Psychiatrist
4,688 satisfied customers
Its kind of imbarrising.. I did realize I could chat to some
its kind of imbarrising.. I did realize I could chat to some one on here … read more
Therapist Leslie
Therapist Leslie
Masters, Professional Psychology
5 satisfied customers
Disclaimer: Information in questions, answers, and other posts on this site ("Posts") comes from individual users, not JustAnswer; JustAnswer is not responsible for Posts. Posts are for general information, are not intended to substitute for informed professional advice (medical, legal, veterinary, financial, etc.), or to establish a professional-client relationship. The site and services are provided "as is" with no warranty or representations by JustAnswer regarding the qualifications of Experts. To see what credentials have been verified by a third-party service, please click on the "Verified" symbol in some Experts' profiles. JustAnswer is not intended or designed for EMERGENCY questions which should be directed immediately by telephone or in-person to qualified professionals.

Disclaimer: Information in questions, answers, and other posts on this site ("Posts") comes from individual users, not JustAnswer; JustAnswer is not responsible for Posts. Posts are for general information, are not intended to substitute for informed professional advice (medical, legal, veterinary, financial, etc.), or to establish a professional-client relationship. The site and services are provided "as is" with no warranty or representations by JustAnswer regarding the qualifications of Experts. To see what credentials have been verified by a third-party service, please click on the "Verified" symbol in some Experts' profiles. JustAnswer is not intended or designed for EMERGENCY questions which should be directed immediately by telephone or in-person to qualified professionals.

Show MoreShow Less

Ask Your Question

x