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Hello,I am Dr. Aren, I will help with your question.Use of Macrobid may cause an arthritis like flare up of joint pains.This may not respond to NSAIDs, she may need help from a Rheumatologist if the pain becomes severe.It will needs drugs other than normally used.
Yes, it would be too late to prevent any further drug reactions.
Yes, the Nitrofurantoin can cause a Rheumatoid Arthritis type of arthritis in the joints causing severe pain. This definitely needs specialised help.
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I wish your wife an early recovery and good health .