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Ask Dr.Saleem Your Own Question
Dr.Saleem, Doctor
Category: Medical
Satisfied Customers: 2310
Experience:  MBBS
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My son had an DNA gene test done to see which

Customer Question

My son had an DNA gene test done to see which antidepressants work best for him. The MTHFR tested low activity C677T: T/T A1298C: A/A.
JA: Have you seen a doctor about this yet? What medications are you taking?
Customer: Yes, Dr. Duffy. He takes Desvenlafaxline 50mg and methylpro 15 mg My concerns are
JA: What medications do you take daily? Are you allergic to any medications?
Customer: Only antidepressant methylpro. no allergy. My concern is with the methylpro. Is it safe to take 15mg and for a long period of time?
JA: Anything else in your medical history you think the doctor should know?
Customer: I also had the gene testing done. My MTHFR is intermediate activity
Submitted: 1 month ago.
Category: Medical
Expert:  Dr.Saleem replied 1 month ago.

Hello and welcome to JA. Dr Saleem here. Will be answering you shortly

Expert:  Dr.Saleem replied 1 month ago.

Its perfectly safe to take methylfolate especially with intermediate MTHFR activity. What you can do is to reduce your dose to 10 mg for a month and see if you continue to feel as good as you have been with 15 mg. Thats how you can taper or re-adjust the dose of activated folate as per your body requirements.

You should also add B12 vitamin and magnesium to your supplements as these tend to reduce the side effects of Methylpro such as agitation, restlessness etc.

Hope it helped.

Let me know if you have any further queries

Expert:  Dr.Saleem replied 1 month ago.

let me know if you have any further queries.

Please reward a 5 stars rating if you are satisfied.

Wishing you a healthy life.