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I suffer from severe fatigue and low mood for probably 20…

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Hi, I suffer from severe...
Hi, I suffer from severe fatigue and low mood for probably 20 years ( male and 35 yrs old) gps have mainly blamed depression on it but I think it is the other way round. My blood tests were all good, do you have any ideas on what it could be, what more can be done re tests as it must be something rare? All common causes have been eliminated thanks Peter
Submitted: 10 months ago.Category: Medical
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6/24/2017
Doctor: Dr. Arun Phophalia, Doctor replied 10 months ago
Dr. Arun Phophalia
Category: Medical
Satisfied Customers: 37,786
Experience: MBBS MS. Post doctoral fellowship in Sports Medicine. General surgeon and sports medicine specialist
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Doctor: Dr. Arun Phophalia, Doctor replied 10 months ago

Hello Peter,

Let me first give you the common cause of chronic fatigue and then we will discuss it further;

Thyroid disease

Connective tissue diseases

Chronic anemia

Neoplastic disease

Chronic infections like Epstein Barr virus

Endocrine diseases (Addison disease).

Chronic fatigue syndrome

Myasthenia Gravis.

You would need following investigations:

Complete blood count (CBC)

Liver function tests

Thyroid function tests

Erythrocyte sedimentation rate (ESR)

Serum electrolyte level measurement

Immunoglobulin M (IgM)/immunoglobulin G (IgG) coxsackievirus B titer

IgM/IgG human herpesvirus 6 (HHV-6) titer

IgM/IgG C pneumoniae titer

Autoimmune panel

Anemia panel.

Please feel free for your follow up questions.

I would be happy to assist you further, if you need any more information.

Thanks for using Just Answer.

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Doctor: Dr. Arun Phophalia, Doctor replied 10 months ago

There is a chronic condition called fibromyalgia which has fatigue as a significant manifestation with depression. Following investigations are advised for it:

1) Thyroid-stimulating hormone

2) 25-Hydroxy vitamin D level: Low levels can cause muscle pain and tenderness

3) Vitamin B-12 level: Very low levels can cause pain.

4) Iron studies including iron, total iron binding capacity, percent saturation, and serum ferritin

5) Magnesium: Low levels can lead to muscle spasms, which are common in fibromyalgia; magnesium supplementation can also improve symptoms in some fibromyalgia.

6) The erythrocyte sedimentation rate (ESR)

7) Antinuclear antibody (ANA)

8) Rheumatoid factor

9) Sleep studies

10) Antipolymer antibody assay; present in approximately 50% of patients with fibromyalgia. This biologic marker may provide conclusive evidence for a subgroup with fibromyalgia.

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Doctor: Dr. Arun Phophalia, Doctor replied 9 months ago

Was this information helpful to you? I would be glad to answer any further questions.

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