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Dr. David
Dr. David, Board Certified Physician
Category: Medical
Satisfied Customers: 46952
Experience:  Experienced Physician trained in New York City. I'm ready to help.
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Dr., Where do you get the 32 to 68?

Customer Question

Dr. David,Where do you get the 32 to 68?
Submitted: 5 months ago.
Category: Medical
Expert:  Dr. David replied 5 months ago.

Hello, this is Dr. David. I am reviewing your question now and will be with you momentarily.

Expert:  Dr. David replied 5 months ago.

you gave me the study where you had that data for discordance for lobular cancers when they metastasize.

Customer: replied 5 months ago.
I told you that. There were other numbers as well. 15%. 52%. etc. I really need your opinion on this. You are an oncologist. I need to know how likely YOU think it is.
Customer: replied 5 months ago.
I really hope that it is actually a small number.
Customer: replied 5 months ago.
Are you telling me that with ductal, the PR+ changes to PR- more than a third of the time? Just curious.
Customer: replied 5 months ago.
Please please tell me it is highly unlikely for indolent lobular to have chemo change the PR status (only if you think that is true)
Expert:  Dr. David replied 5 months ago.

we looked at a study which quoted those numbers.

I tried to find the study you posted in your questions to me.

you have way too many questions

I couldn't find the question.

Expert:  Dr. David replied 5 months ago.

you are so worried about PR changing before.

you had a period where you found a study showing that PR changing from chemo was a bad thing

and that PR negative means your cancer was going to come back and be more aggressive.

you read all of these studies.

Customer: replied 5 months ago.
No, it is just one of the numbers I gave you. I really wish you would tell me how likely YOU think it is since you see actual oncology. These studies have numbers all over the map. Please--you told me that in lobular you'd never seen it. How much worse can it be in ductal?
Customer: replied 5 months ago.
I just need some assurance that my pr has not turned negative. The really positive Er/Pr was my "secret weapon". Now that might be ruined.
Expert:  Dr. David replied 5 months ago.

I have told you my experience with lobular carcinoma patients and their mets already

Expert:  Dr. David replied 5 months ago.

I saw six patients, all had kept their ER and PR status.

Customer: replied 5 months ago.
could you just say something encouraging. I know you go to tumor boards. Is it common for pr to turn negative?
Expert:  Dr. David replied 5 months ago.

I have told you already, it is not common for PR to turn negative at first metastasis.

Customer: replied 5 months ago.
it won't happen to me with my positive +++ er and pr, right?
Expert:  Dr. David replied 5 months ago.

you don't need to worry about mets.

you need to calm down your worries.

Customer: replied 5 months ago.
you didn't answer my question
Expert:  Dr. David replied 5 months ago.

you don't have to worry about mets.

Customer: replied 5 months ago.
but my question was whether my pr+++ turned negative from the chemo---which will in turn cause mets, because the AI's won't work very well
Expert:  Dr. David replied 5 months ago.

you don't have mets now

so there is nothing to biopsy to know if your PR is negative