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Is this from a urinalysis result?
Do you have other lab values to share?
Leukocyte esterase is an enzyme produced by white cells. The urinalysis detects leukocytes in the urine, which is thus suggestive but not diagnostic for bacteria. False-positive tests result from specimen contamination. False-negative tests result from concentrated urine, glucose in the urine, bilirubin in the urine, and medications, including rifampin, phenazopyridine, and ascorbic acid.
The presence of more than five leukocytes is considered significant pyuria. Leukocytes in the urine are indicative of injury to the urinary tract, which may or may not be due to infection. Other causes of pyuria include stones, strictures, neoplasm, genitourinary tuberculosis, glomerulonephropathy, or interstitial cystitis. Leukocyte counts will vary by the state of hydration, method of collection, and degree of injury to the urinary tract.
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