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Hello I have more than 20 years experience a physician
Just to get you understand erosions of the sacroiliac joint, I want you to use the analogy of a nut with a washer in the front end of your car.
The sacro iliac joint uses a fibrous washer to cushion the effect of your weight and the force of gravity, and as we are getting old, this 'washer' begin to 'wear' just like in nuts and bolts washers
The HLA-B27 genes are just differentiating markers found in person with more susceptible to 'inflammation (causing pain) in the joints' as this 'wearing' process continues (called erosion in medical terms).
Humira inhibits some of the factors that 'propagate this inflammation and pain. It is called the TNF or (tumor necrosis factor)
SO THE ANSWER IS YES
Humira with benefit you, but you may need an additional medicine for pain in the first few days, if you are feeling severe pain. This is because t takes a few days for the FULL effect of humira begin to control the inflammation