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Hi there. Most blister will heal on their own if pressure on the wound is avoided and they are left open to the air. Most swelling associated with blisters will go down within a couple days with elevation of the foot above the level of the heart. If there is redness or pus or you are having fever, you should have the foot examined right away. Similarly, if you are prone to blood clots or are having pain in your calf, you should make an appointment to see your family doctor.