I'm currently suffering from a major depressive episode since the last 11 or so weeks and I wish to know if you can verify my concerns and possible solutions.
I have done a decent amount of at home research on neurotransmitters and believe that I may have an overabundance of acetylcholine in the brain. If true thus would have been a result of taking excessive amounts of fish oil over the course of 4/5 months, which is a known source of choline. Some research that I have looked stated that when acetylcholine levels are too high in the brain it inhibits the transmission of the other neurotransmitters such as serotonin, dopamine, & norepinepherine, thus leading to depression.
What leads me to believe this are a combination of two things.
When this episode first occurred it started as mild anxiety (shortness of breath) which then lead to intense anxiety. Following that came severe depression and the anxiety was relegated to the mornings. After seeking treatment I was put on 20mg of Escitalopram
. From there my depression began wane over the next 2 weeks and the anxiety was all but gone. I then went back onto my regular vitamins and supplements which included the high (but not as high) doses of fish oil for about about 3 weeks. After 5 weeks total on the medication I then relapsed and fell into another severe depressive state.
2. Intense and vivid dreams
I have noticed intense and vivid dreams whilst in this depressive state. I understand that this is a common symptom of depression but my vivid dreams and higher incidence of disturbed sleep began occurring prior to the depressive episode. I think this may further indicate high levels of acetylcholine as it is associated with REM sleep.
My questions are:
1. Do you think its possible that high doses of fish oil over an extended period of time could increase my acetylcholine levels to cause a depressive state? and if so
2. What are my solutions? I am considering taking small doses of diphenhydramine
to see its effects on my sleep and sleep cycles due to its anticholinergic effects. I am also considering taking an acetylcholine precursor such as CDP-choline which penetrates the blood brain barrier quickly to see if it makes me feel worse. Are anti-depressants an option if all this is true. Or should I just ride it out untill my neurotransmitter levels balance themselves on their own, and how long would this take?