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It would depend upon the severity of the symptoms being treated with the Medrol dosepak. If the symptoms are more severe, then it would be better to take some medicine tonight, but if the symptoms are less severe, it would be OK to start the dosepak in the morning.
If you are having severe symptoms and you were given the 6-day dosepak, a common approach would be to take two pills tonight and then take six pills tomorrow, and continue through the remainder of the dosepak, except taking a single pill off each of the fourth and fifth day of the 6 day dosepak. So, day one will still be 6 pills, day two will be 5 pills, day three will be 4 pills, day four will be 2 pills, and day five and day six will be one pill each day.
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