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Hi this is Dr Stan here to help you today. The antibiotic should resolve the sinus infection. Since the Ultrasound and blood test for blood clot were negative that should not be a problem either. The "Knot" could be an irritation such as epididimitis would would be painful to touch or when walking. Is the knot in his scrotum or on the skin next to scrotum? If next to it, then it could be a sweat gland that is blocked or a hair follicle that has become infected. In either case warm moist compresses to the area should resolve this in a few days. If this persists, a doctor should evaluate and determine the best treatment. I hope this helps and I am here to answer any additional questions you may have. If no further questions, a positive rating is appreciated.
It certainly does not sound like cancer nor an infection in the leg. What you are describing does not need an ER visit at this time. Try the warm moist compresses. The swelling should resolve in a few days.
You are welcome.