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Tramadol causes itch (3% to 12%), skin rash (1% to <5%), urine abnormality (1% to <5%), urinary retention (<1% to <5%), and so forth.
Symptoms of overdosage with Tramadol are respiratory depression, somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, constricted pupils, seizures, bradycardia, cardiac arrest, and death.
Deaths due to overdose have been reported with abuse and misuse of tramadol.