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Would a history of germ cell testicular cancer (embryonal…

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Would a history of germ...
Would a history of germ cell testicular cancer (embryonal carcinoma) in 2006 with no history since of recurrent disease or other complications be an absolute contraindication for cross sex (male to female) hormone therapy? Specifically estradiol and spironolactone?
Submitted: 2 years ago.Category: Medical
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Answered in 1 hour by:
2/16/2016
Doctor: DrRussMD, Board Certified Physician replied 2 years ago
DrRussMD
DrRussMD, Board Certified Physician
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Hello

I see no reason is should be an absolute contraindication.

These tumors produce testosterone, and would not, in theory, be stimulated to recur from estradiol or spironolactone.

In fact, one might even assume that treatment to be suppressive of such a tumor.

However, you must coordinate with an endocrinologist on this.

Since you were cured of the cancer there is no reason to suspect you can not do this.

OK, so that is an initial answer….

Please use reply to expert if you have further questions. When you are ready, please click a positive rating [hopefully excellent]. If you forgot something, come back. I am here daily.

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Customer reply replied 2 years ago
Thank you for your response! My limited Google searching turned up this article published in 2007 that has me concerned ...http://press.endocrine.org/doi/full/10.1210/en.2007-1318Any thoughts?
Doctor: DrRussMD, Board Certified Physician replied 2 years ago

The article relates to fetal exposure [in the womb].

So I don't think so.

However, again, you must be working with an endocrinologist, and your cancer doctor,.

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