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Hi there. Thank you for your question.I will be helping you out with your queries.There is no definitive evidence to suggest that Nigen is effective.There is insufficient evidence at the moment in terms of randomized controlled trials or clinical trials to advocate its use.So, you may end up wasting your money on this actually.It is however seen that it is safe and most people do not experience any side effects taking the recommended amount each day i.e. 10 mg.Here is an article that you might want to read on this:http://www.webmd.com/vitamins-supplements/ingredientmono-1016-nadh.aspx?activeingredientid=1016&activeingredientname=nadhLet me know if you have more questions.Rate me by clicking on one of the rating options below.Kind regards