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Dr. David
Dr. David, Board Certified Physician
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does oxymorphone or opana er accumulate in your system making

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does oxymorphone or opana er accumulate in your system making an overdose more likely. If not how much of either would cause an overdose?
Hello, this is Dr. David. I have read your question and am ready to help.

opana (oxymorphone) does not accumulate in the system. every 7-12 hours the dose of oxymorphone is cut in half in your body so in 35 hours to 60 hours, the medicine is completely out of your system. it is a very slow acting and long acting medication because of this long 1/2 life.

the overdose for mice that kills 50% of mice is about 400mg/kg of mice.

so for a regular human of 70kg would be 28,000mg of opana.

so you shouldn't be scared of overdosing from opana.

let me know if you have questions.
Customer: replied 4 years ago.

thank you but I have one last question. what does a concentration of 286 ng/ml mean on an autopsy report? The coroner considered this oxymorphone intoxication.

this is the amount of oxymorphone in the blood per ml of body fluid like blood.

that is 286 nanograms per milligram of fluid.

if the coroner is considering this oxymorphone intoxication then that shows that there was a very high dose of oxymorphone in the body when the patient died.

did the coroner rule that this was the cause of death?
Customer: replied 4 years ago.

yes he did we are just trying to figure out how many pills at 5mg he would had to have taken to get to that concentration


Thank you so much for your reply

40 mg of opana results in a peak concentration in the blood of

2.50 ng/ml


so you need 40mg x 114 or 4576mg of opana or possibly 915 5mg pills could have been ingested.


see the info here

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