Hello, and welcome.
My apologies that you did not receive an earlier answer.
If your wife ordered the tickets online and misspelled her name by accident, herself, that's one thing; however, if the reservation was made directly with the airline, on the phone or even online and your wife spelled her name correctly, but the airline misspelled it, they should be willing to change it.
Because the mistake is so obvious (they left out the 'r' in 'Karen') When she shows her ID at TSA Security Screening, they might not question it. However, if they do, they can do additional screening from other types of ID your wife has and also tap into publicly available databases to which they have access. If your wife has any of these other forms of ID, in addition to her driver's license, she should bring them with her:
While all sources of ID and the ticket/boarding pass need to match, in this case, I don't think she should have much of a problem, since the misspelling is so obvious.
IF additional screening is needed, please leave additional time to get to the airport about 2 hours earlier than usual.
Try once again, to get the airlines to change the spelling on her ticket, especially if it was their fault and not your wife's.
I hope this helped and all goes well!
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