Hello, my name is ***** ***** I will be the immigration attorney helping you today.
If your mother entered legally with a B2 visa and you are 21 years old and a US citizen, then YES you can file all the applications for your mother to receive her green card here in the US and she does not have to depart the US in order to do this.
Good luck to you during this process and I hope this answer has helped you!
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