Hello, my name is ***** ***** I will be the immigration attorney helping you today.
In order to have a chance of approval the attorney will need to prepare a very good letter and package with evidence. The most important thing to show is that your brother's wife will suffer from extreme hardship if he had to leave the US or if she had to go to the US with him. The best way to show this is usually by providing proof that his wife suffers from a medical condition for which she receives treatment in the US. This does not necessarily have to be something very serious.. it can be a combination of less serious conditions for example: diabetes, high blood pressure, asthma, mental conditions like depression, anxiety. This is just some of the most common ones. She would need to provide a letter from a doctor explaining the condition she has. Additional things they can provide (not as important as medical but helpful) would be proof that the wife and children depend on your brother financially. Provide tax returns and W-2 for the last few years to prove what he earns along with list of all bills and copy of bill statements to show what they have to pay. If either one of them are going to school or will be going to school, that should be mentioned also.
This will help his chances but it's important that the explanation be written well.
Good luck to you during this process and I hope this answer has helped you!
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