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are you on any other medications or supplements?
You can start at the*****Johns Wort and then increase weekly as needed for your symptoms.Also, studies show that daily exercise (30 minutes a day or more) can be as effect (or more) in the treatment of anxiety and depression as well, so I always recommend to patients to start an exercise program as well if they are being treated for depression and/or anxiety.
As far as drug interactions, typically St Johns Wort will increase the metabolism of certain medications because of its metabolism in the liver. I don't see any significant interactions listed between St johns Wort and the ingredients in cocodamol