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With a high cortisol, supplements may not be safe so you should avoid any till it is controlled.
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Adiponectin levels are lower in obese than in lean people. Visceral fat deposition has been shown to be an independent negative predictor of adiponectin. Thus, most features of the metabolic syndrome's negative associations with adiponectin have been shown. The primary mechanisms by which adiponectin enhance insulin sensitivity appears to be through increased fatty acid oxidation and inhibition of livr glucose production. In summary, adiponectin in addition to possible anti-inflammatory and anti-atherogenic effects appears to be an insulin enhancer, with potential as a new treatment modality of the obesity.
But with the high cortisol, unless the primary issue is controlled, Adiponectin is unlikely to work to reduce weight.
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