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Dr. Saha
Dr. Saha, Doctor (MD)
Category: Health
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Experience:  35 years of experience
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I was prescribed a Medrol DosePak last Wednesday. I took the

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I was prescribed a Medrol DosePak last Wednesday. I took the 6 pills that day as prescribed. Second day I had only took one pill as I had a severe allergic reaction. Burning itching skin,redness and burning to throat,ears, scalp. I was taking Xyzal with this medication. I had to stop taking after the second day. How long should this medication stay in my system? What was very strange as the next day after taking, I took another Xyzal and the symptoms came back ( but milder) It seemed to me that the combination of the two exacerbated the symptoms. It has now been three days since I stopped the medrol, I need to take a Xyzal, for my allergies, but in fear of the Medrol still in my system...btw, I have taken Xyzal for over 2 years with no problems
Thank you for your question,
I’m Dr. Saha and I’ll try to help you.
You can take Xyzal.
Medrol's half life after taking orally is 2.5-3.5 hours.
So it is unlikely to be in your system after 3 days.
You can read this link on it.
There is also no reported interaction of Medrol with Xyzal.
It is often prescribed together.
I hope this information helps.
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