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Muscular shaking can be due to the MS as well.
Klonopin withdrawal should not be present since your sister is on high dose of valium.
This can be due to the different issue from panic disorder.
Muscular disease from MS can cause this.
It is better to see her neurologist and discuss this issue.
If she is not drowsy during daytime, then the valium dose can be increased or a muscle relaxant like baclofen can be added to control her shakiness.
We wonder if it is just anxiety making her shake, phychological so to speak. It comes and goes. She was just at the neurologist in September who says she is doing good. She can really work herself up. We really don't want to increase the valium, she'll just need more and more, and the withdrawal is awful. I wish there was a way to reduce her panic attacks besides drugs.