GMC Troubleshooting Questions? Ask a Mechanic for Answers
There is not a fuel filter for each cylinder.
What you are describing is a classic secondary ignition misfire, and I think you're on the right track, but just haven't pinned it down yet.
I am attaching a bulletin for you to review, it talks about the plugs and coils. You should only be using the specified AC Delco plugs and coils, first of all. Secondly, note that the bulletin says that the offending coil/plug may not be the same cylinder that's setting a misfire code. This bulletin will show you what to look for, and will probably fix your issue right up once you've gone through this inspection and replaced what needs to be replaced.