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You can try a Corn Starch Baby Powder or Plain Cornstarch, not Talcum powder. The Corn Starch dusted on the area will keep a barrier between the skin and Depends.
This keeps the moisture locked away which adds to the chaffing. The Creams are moist and do not absorb the perspiration which adds to the chaffing.
I hope this helps. When my son was in Diapers I used this method and never had a problem with diaper rash or chaffing. We also use it on my Mother-in-law who is also in Depends. Joan