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Does it seem to misfire more at idle or while going down the highway?
Does the check engine light flash? Are you getting any codes other then misfire?
Do you have the V6 or V8 engine? Does it seem to misfire at idle too? Thanks.
Considering what has been replaced the only things left are pretty much engine mechanical such as valve, camshaft, rocket arm, ect or injector. I would start by doing a compression test to verify compression is similar to the other cylinders and if not next step is to do a leakdown test to see where compression is being lost. If compression is good then I would go ahead and replace injector. Let me know if you have more questions or if there is anything else I can do to help. Thanks.
Was the trouble code P0302 or P0352?