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The blower motor is located under the passenger side of the dash below the glove box. I do not recommend flushing water through the system as you will have water entering the inside of your truck because the AC system evaporator and case are located under the dash inside the truck.
Do you have air coming out of any of the vents, like the floor ducts, defroster ducts or the dash vents?
Does the blower speed change any from the lowest speed setting to the highest?
Does the air flow out of the vents increase when you switch from normal AC to the MAX AC setting. The air flow should speed up when switched to MAX AC.
How many miles on your F250?
Ok. This is sounding like the evaporator is plugged up. By this I mean the fins where the air flows through is plugged with dirt and debris stopping up the air flow from the blower fan. You can either have the evaporator replaced or have an AC evaporator service done in which this service applies a foam cleaner between the blower fan and the evaporator and the blower fan forces the cleaner through the fins of the evaporator and washes the dirt and debris off the fins allowing the air flow to return.