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An Escape can make it to about 280,000 miles before the repair expenses over way the cost of keeping the vehicle. The Escape is know for transaxle failure, catalytic converter failure, and damage to the 4x4.
The best thing to do outside of normal maintenance is to drain and fill the trans yearly. It takes about 10 minutes, to remove the oil drain plug and refill with about 3.6 quarts of Mercon 5. If you get a misfire, immediately repair it or the converters will clog up instantly from raw fuel. Always make sure all 4 tires are the same brand, size and age.